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Use of phenolic acids effective part in dandelion for treating stomatocace

A technology for effective parts and oral ulcers, applied in the field of medicine, can solve problems such as discomfort, achieve the effects of improving curative effect, avoiding liver first-pass effect, and increasing drug concentration

Inactive Publication Date: 2007-08-29
赵昱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many new oral buccal drug preparations that have appeared recently, such as watermelon cream buccal tablets, Huasu tablets, and lysozyme buccal tablets, have made progress in taste, sterilization, and anti-inflammation, but some products are not suitable for lactating women. Patients with hyperthyroidism and iodine allergies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of effective fractions of total phenolic acids from dandelion extract

[0025] Take 10 kilograms of air-dried samples of dandelion medicinal materials, cut into small pieces, heat and extract twice with 50% ethanol aqueous solution, use 8 times the amount for the first time, and use 6 times the amount for the second time. The first extraction was 2 hours, the second extraction was 1.5 hours, concentrated, loaded on the treated macroporous adsorption resin, washed with water until the color was lighter, and then eluted with 50% ethanol until the color was light, and the eluent was reduced. Compression recovery, spray drying to obtain raw material fine powder, which is the effective part of the phenolic acid compound of the dandelion plant extract in the present invention. The colorimetric method is used for content measurement: the content is calculated according to the standard curve, and the result is that the content of total phenols in the da...

Embodiment 2

[0026] Example 2 : Preparation formula one of dandelion plant phenolic effective part buccal tablet

[0027] Feed according to the prescription amount, pass 75 grams of dandelion extract dry powder raw materials, 75 grams of microcrystalline cellulose, and 75 grams of starch through an 80-mesh sieve, add 8 grams of aspartame, mix, sieve, and mix with 60% Prepare wet granules with ethanol, dry in an oven at 50°C for 2 hours, add 2 grams of peppermint essence and 10 grams of magnesium stearate, mix well, and tablet to make 1000 tablets, the weight of each tablet is about 250 mg.

Embodiment 3

[0028] Example 3 : Preparation formula 2 of buccal tablet of phenolic acid active parts of dandelion plant (sweet orange dandelion buccal tablet)

[0029] (1) Preparation of dandelion spray-dried powder: same as Example 1.

[0030] (2) Pass 75 grams of dandelion dry powder, 300 grams of microcrystalline cellulose, and 300 grams of starch through an 80-mesh sieve, add 100 grams of powdered sugar, 10 grams of mannitol, and 40 grams of aspartame, mix well, sieve, and mix After homogenization, use 60% ethanol to make wet granules, dry in an oven at 50°C for 2 hours, add 30 grams of liquid orange essence and 40 grams of magnesium stearate, mix well, and make 1,000 oval-shaped special-shaped punched tablets, with a weight of about 900 mg. / piece.

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PUM

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Abstract

The present invention relates to a dandelion plant phenolic acid effective component for preventing and curing herpes simplex virus infection and its application in preparation of medicine for preventing and curing ulcerative stomatitis. The invented dandelion plant phenolic acid effective component is obtained by using fresh dandelion plant or dried dandelion plant and making it undergo the processes of alcohol and water extraction, column chromatography and alcohol solvent elution, etc. Said effective component can be made into lozenge, powder preparation, spray, granules and oral solution, etc.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to buccal tablets, powders, sprays and oral patches prepared from effective parts of dandelion plant phenolic acids as the main ingredient. It has remarkable effects in the prevention and treatment of oral ulcers caused by factors such as virus infection, and can be expected to become a drug for preventing and treating oral ulcer diseases caused by type I herpes simplex virus infection and other causes. technical background [0002] Oropharyngeal diseases are a major disease of human beings, and oral ulcers are common and frequently-occurring diseases with an incidence rate of 10-30%. Traditional Chinese medicine believes that oral ulcers belong to the categories of "oral sores" and "chancres", which occur in all age groups, and affect eating and sleep due to strong spontaneous pain during attacks. Its etiology is complex and there are many types of diseases. The theory of tradit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/288A61K9/12A61K9/14A61K9/20A61K9/70A61P31/22A61P1/02
Inventor 李峰瞿佳李校堃白骅于荣敏卢付生巫秀美赵昱
Owner 赵昱
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