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Medicine composition for treating osteoporosis

A composition and drug technology, applied in the direction of drug combination, bone disease, medical formula, etc., can solve the problems of inconvenient portability, low quality control standards, and low content of active ingredients

Inactive Publication Date: 2011-04-06
江苏省药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese patent medicines such as Gusongbao Tablets, Gusongkang Mixture, Guyuling Capsules, Liuwei Zhuanggu Granules, Shengu Powder, Xianling Gubao, etc. Some of these medicines are inconvenient to carry or take, and some have more medicinal flavors. The content of active ingredients is small, the quality control standard is low, and it is difficult to achieve satisfactory curative effect in the treatment of a large number of clinical cases
Modern traditional Chinese medicines such as total saponins of Dipsacus (coming on the market) and total flavonoids of Epimedium (in clinical practice) have clear active ingredients, precise efficacy, and controllable quality, but their effects are single and fail to reflect the concept of overall regulation in traditional Chinese medicine. Based on the theory of traditional Chinese medicine, it is of great significance to use modern medical theory to develop a medicine for osteoporosis with clear active ingredients, definite curative effect and controllable quality.

Method used

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  • Medicine composition for treating osteoporosis
  • Medicine composition for treating osteoporosis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Extracts of Epimedium and Salvia Miltiorrhiza were prepared by decoction:

[0030]Preparation of Epimedium extract: Take 2000g of Epimedium, add 70% ethanol 25 times the weight of the medicinal material, reflux extraction 3 times, extract for 2, 2, and 1 hour respectively, filter, combine the extracts, and recover the ethanol until it is free of alcohol , and concentrated into an aqueous solution of 1g crude drug / ml, extracted with petroleum ether, the aqueous layer was extracted three times with ethyl acetate, the ethyl acetate was recovered under reduced pressure to nearly dryness, dried, pulverized, and passed through a 55-mesh sieve to obtain brown-yellow Epimedium The finished product of total flavonoids has a weight of 44g, and the content of total flavonoids in Epimedium is 54.47%.

[0031] Preparation of Salvia miltiorrhiza extract: Take Danshen medicinal material and crush it into coarse powder 2000g, add 70% ethanol which is 8 times the weight of medicinal mat...

Embodiment 2

[0033] Combined decoction method to prepare the extracts of Epimedium and Salvia miltiorrhiza: Take 1000g of Epimedium and 1000g of Danshen crude powder, mix them, add 70% ethanol 25 times the weight of the medicinal materials, reflux extraction twice, extract for 2 and 2 hours respectively, filter , combine the alcohol extracts, recover ethanol until there is no alcohol, and concentrate it into an aqueous solution of 1g crude drug / ml; add water 20 times the weight of the medicinal material to the dregs, decoct twice for 2 and 2 hours respectively, filter, and extract with water solution, concentrated under reduced pressure into an aqueous solution of 1 g crude drug / ml. Combine alcohol and water to extract the concentrate, extract 3 times with ethyl acetate, adjust the pH of the aqueous layer to 2 with 1N HCl after ethyl acetate extraction, then extract 3 times with ethyl acetate, combine the 2 ethyl acetate layers, and recover acetic acid under reduced pressure Ethyl ester, d...

Embodiment 3

[0035] Take Example 1 Epimedium extract 20g, Salvia miltiorrhiza extract 20g, add starch 60g, mix uniformly, fill capsule or make tablet after granulating.

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Abstract

The present invention discloses a medicine composition with the function of promoting blood circulation and removing blood stasis for effectively curing osteoporosis. Said medicine composition contains the Chinese medicinal materials of epimedium and salvia root. Besides, said invention also provides its preparation method.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating osteoporosis, in particular to the pharmaceutical composition of epimedium and salvia miltiorrhiza and its medical application. The active ingredients in the extract of the composition are Epimedium flavonoids, Salvia quinones (Salvia ketones) and salvianolic acids (Salvianolic acids), and these three types of active ingredients are Epimedium The total content of total flavonoids, total tanshen ketones and total phenolic acids of salvia miltiorrhiza must not be less than 50% of the total weight of the extract. The pharmaceutical composition can be used to make medicine for treating osteoporosis. Background technique: [0002] Osteoporosis is a kind of disease characterized by decreased bone mass, abnormal microstructure of bone tissue and increased risk of fracture. It is common in the elderly, especially postmenopausal women, with a high incidence and great harm. According to statis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P19/10A61K36/537
Inventor 韦英杰舒斌石金城
Owner 江苏省药物研究所有限公司
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