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Externally-applied zeolite hemostat and its preparation

A preparation process and a technology for hemostatic agents, applied in the field of external hemostatic agents and their preparation, can solve problems such as inconvenience in treatment, and achieve the effects of improving hemostasis ability, improving logistics support ability and simple preparation process

Inactive Publication Date: 2007-09-05
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And because of the problem of zeolite absorbing water and generating heat, it is necessary to remove the dry zeolite particles first during debridement, and then rinse the wound surface with a large amount of water (much more than the usual debridement water volume) to remove zeolite and reduce the calorific value. Inconvenient for further treatment after hemostasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Grinding 5A zeolite into particles with a diameter of 0.50 mm to 0.75 mm; mixing the ground 5A zeolite with 20% sodium nitrate solution at a solid-to-liquid ratio of 1 g / 10 mL, and reacting at 100 ° C 2h, decant the supernatant, repeat 3 times to obtain Na-type zeolite; mix the modified Na-type zeolite with silver nitrate and zinc nitrate with a concentration of 0.1mol / L at a solid-to-liquid ratio of 1g / 10mL Mix, adjust the pH of the mixed solution to 5-7 with nitric acid, react at 60°C for 4 hours, wash with deionized water until there is no Ag in the solution + and Zn 2+ , and dried until no crystal water remains to obtain the modified Ag-Zn zeolite, the molar concentration ratio of silver nitrate and zinc nitrate is 1: 1; the Ag-Zn zeolite with a weight of 80% dry dehydration and a weight of 20% % of the alginate material is mixed and sterilized by radiation. Take the external zeolite antibacterial and hemostatic agent of this embodiment. After the anima...

Embodiment 2

[0033]Example 2: Mix 83% by weight of dry dehydrated Ag-Zn zeolite with 17% by weight of alginate material, and sterilize it by radiation. The other steps are the same as in Example 1.

Embodiment 3

[0034] Embodiment 3: Take 81% by weight of dry dehydrated Ag-Zn zeolite and mix it with 19% by weight of alginate material, and then sterilize it by radiation. The other steps are the same as in Embodiment 1.

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Abstract

An exterior-applied antibacterial styptic powder is prepared from 5A zeolite through pulverizing to become (0.5-0.75)-mm particles, preparing Na-type zeolite from it, carrying Ag and Zn ions by ion exchange, drying, mixing it with alginate powder, and irradiation sterilizing.

Description

technical field [0001] The invention relates to a hemostatic agent for external use and a preparation method thereof, in particular to a zeolite antibacterial hemostatic agent for treating fatal large-vessel hemorrhage uncontrollable by conventional hemostatic measures and a preparation process thereof. Background technique [0002] Uncontrolled bleeding has historically been the leading cause of death before hospital admission. Statistics show that 50% of the wounded in the Vietnam War died of hemorrhage; during the War to Resist US Aggression and Aid Korea, 32.4% of the casualties in our army died of hemorrhage. . In addition, hemorrhage is one of the leading causes of death from civilian trauma in peacetime. According to the report of Trauma in Peacetime in Denver, USA, among the 289 civilians who died of trauma in 1992, 39% were caused by hemorrhage. Therefore, early and effective control of bleeding can help us save more lives. [0003] The traditional methods of he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61P31/02A61P7/04A61K31/734
Inventor 陈绍宗蒋立李靖李学拥
Owner FOURTH MILITARY MEDICAL UNIVERSITY