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Method for preparing heparin isinglass nanometer grain and heparin encapsulization heart closure device

A nanoparticle and microencapsulation technology, used in medical science, surgery, etc., can solve the problems of decreased activity and fast metabolism of heparin, and achieve the effects of ensuring stability, anticoagulant endothelial cell growth, and shortening the healing process.

Inactive Publication Date: 2007-09-19
孙勇 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing heparin gelatin nanoparticles and a heparin microencapsulated heart occluder in order to solve the defects of heparin’s fast metabolism in the human body and its activity after being grafted onto the surface of polymer materials.

Method used

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  • Method for preparing heparin isinglass nanometer grain and heparin encapsulization heart closure device
  • Method for preparing heparin isinglass nanometer grain and heparin encapsulization heart closure device
  • Method for preparing heparin isinglass nanometer grain and heparin encapsulization heart closure device

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specific Embodiment approach 1

[0009] Embodiment 1: In this embodiment, heparin gelatin nanoparticles are prepared according to the following steps: (1) chemically degrade heparin into low molecular weight heparin; Dissolve in gelatin solution, then add Tween-20 with 6-7 times the weight of gelatin to make water phase; (3) Put liquid white oil with 95-105 times the weight of gelatin in a water bath at 40-60°C, and stir while stirring Add the water phase dropwise to form a water-in-oil mixed solution, in which the stirring speed is controlled at 7000-11000r / min; (4) The water-in-oil mixed solution is emulsified in a water bath at 40-60°C for 20-30 minutes, and then changed to an ice-water bath 2±0.1h; (5) After the temperature of the water-in-oil mixture returns to room temperature, add formaldehyde with a mass of 8% to 12% of the water-in-oil mixture to solidify for 30-60min, and then add the water-in-oil mixture with a volume of 2 ~3 times of acetone is used for dehydration and deoiling, the acetone dehydr...

specific Embodiment approach 2

[0015] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the gelatin solution in step (2) is made by dissolving gelatin in distilled water by heating and dissolving in a water bath at 60±2°C. Other steps and selected parameters are the same as those in Embodiment 1.

[0016] The concentration of the gelatin solution in this embodiment has no effect on the spheroidization and preparation of the heparin-gelatin nanoparticles.

specific Embodiment approach 3

[0017] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in step (2), the low molecular weight heparin is dissolved in the gelatin solution at a mass ratio of low molecular weight heparin to gelatin of 0.8-3:10. Other steps and selected parameters are the same as those in Embodiment 1.

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Abstract

The invention relates to preparation methods for heparin gelatin nano-particles and heparin microencapsulation heart occluder. It relates to preparation methods for gelatin nano-particle and heart occluder. It solves the defect of great decline of heparin activity after the speed of metabolism in human becomes quickly and the heparin grafts on polymer surface. The heparin of low-molecular weight dissolves in gelatin solution, and then added to white oil, after emulisification, solidification, dehydration and deoiling to finally obtain heparin gelatin nano-particles. The heart occluder immerges in sodium hyaluronate solutionm and then immerges into sodium hyaluronate suspending liquid containing heparin gelatin nano-particles to obtain heparin microencapsulation heart occluder. The said heparin gelatin nano-particles have good biocompatibility and biodegradability. The said heart occluder ensures the stability of heparin of low-molecular weight in human and has long, stable, slowoperating effects, furthermore the anti-hemagglutination ability is retained.

Description

technical field [0001] The invention relates to a preparation method of heparin gelatin nanoparticles and a heparin-coated cardiac occluder. Background technique [0002] Heparin can be used as an anticoagulant drug, but due to the rapid metabolism of heparin in the human body, frequent injections are required, which brings a lot of inconvenience to patients and also brings other side effects. At present, grafting heparin on the surface of polymer materials can play a role in sustained release, but the activity of heparin grafted on the surface of polymer materials is greatly reduced. Contents of the invention [0003] The purpose of the present invention is to provide a method for preparing heparin gelatin nanoparticles and a heparin microencapsulated heart occluder in order to solve the defects of heparin’s fast metabolism in the human body and its activity after being grafted onto the surface of polymer materials. . [0004] Heparin-gelatin nanoparticles are prepared ...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/12
Inventor 孙勇于波王天群赵阳高峰张永春石秀杰陈伟
Owner 孙勇
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