Extraction method of Chinese medicine of gold buckwheat raw anthocyanin

A technology of proanthocyanidins and extraction method, which is applied in the direction of medical formula, drug combination, medical preparations containing active ingredients, etc., to achieve the effect of simple process and significant antitussive and expectorant effect

Inactive Publication Date: 2007-09-19
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the extraction method of proanthocyanidins from the t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Process and steps in the present embodiment are as follows:

[0016] (1) mechanically pulverizing the traditional Chinese medicine golden buckwheat, and passing the particles through a 50-mesh sieve to obtain golden buckwheat coarse powder;

[0017] (2) Add 800 grams of the above-mentioned golden buckwheat coarse powder into 2000 milliliters of distilled water, stir and extract 3 times; each extraction time is 5 hours, and the extraction temperature is 20° C.;

[0018] (3) Collect and combine the above-mentioned three extracts, filter it to obtain the filtrate, which is the filtered extract; gradually add sodium chloride in the extract, and keep stirring until the saturated sodium chloride is separated out Then filter, and the filtrate is extracted 3 times with the organic solvent ethyl acetate; Add anhydrous sodium sulfate to dry; then filter, and concentrate the obtained filtrate to 1 / 5 of its original volume under reduced pressure;

[0019] (4) Add 3 times the volu...

Embodiment 2

[0021] Process and steps in the present embodiment are as follows:

[0022] (1) mechanically pulverizing the Chinese medicine golden buckwheat, and passing the particles through a 60-mesh sieve to obtain golden buckwheat coarse powder;

[0023] (2) adding 1000 grams of the above-mentioned golden buckwheat coarse powder material to 4000 milliliters of concentration in 20% ethanol aqueous solution, stirring and leaching 3 times; each leaching time is 12 hours, and the leaching temperature is 50 ° C;

[0024] (3) Collect and combine the above-mentioned three extracts, filter it to obtain the filtrate, which is the filtered extract; gradually add sodium chloride in the extract, and keep stirring until the saturated sodium chloride is separated out Filter then, and filtrate is extracted 4 times with organic solvent ethyl acetate; The consumption of ethyl acetate is decided according to the amount of filtrate, adopts the volume ratio of filtrate and ethyl acetate to be 1: 1; Merge t...

Embodiment 3

[0027] Process and steps in the present embodiment are as follows:

[0028] (1) Mechanically pulverizing the Chinese medicine Golden Buckwheat, passing the particles through a 40-mesh sieve to obtain the Golden Buckwheat coarse powder;

[0029] (2) adding 1000 grams of the above-mentioned golden buckwheat coarse powder material to 4000 milliliters of concentration in 10% ethanol aqueous solution, stirring and leaching 2 times; each leaching time is 8 hours, and the leaching temperature is 40 ° C;

[0030] (3) Collect and combine the above-mentioned secondary extracts, filter it to obtain the filtrate, which is the filtered extract; gradually add sodium chloride in the extract, and keep stirring until the sodium chloride is saturated Separate out; Then filter, and the filtrate is extracted 4 times with organic solvent ethyl acetate; The consumption of ethyl acetate is decided according to the amount of filtrate, adopts the volume ratio of filtrate and ethyl acetate to be 1: 1; ...

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Abstract

The invention relates to a craft for extracting procyanidin from the herbal medicine fagopyrum dibotry, belonging to herbal medicine extraction chemistry and chemical engineering field, comprising following steps: firstly smashing the fagopyrum dibotry, screening, extracting the fagopyrum dibotry coarse powder with distilled water or low concentration ethanol water solution, saturating the extraction liquid with sodium chloride, filtering, extracting by organic solvent, drying the extracted organic solvent phase by sodium sulfate anhydrous, then filtering, concentrating in vacuo the filtrate; then adding 3-6 times volume of organic solvent with low polarity to the filtrate concentrated solution, blending, static settlement for 5-12 hours; filtering to get deposit, drying, then getting procyanidin extractive, which has the purity more than 95%, and 0.6-0.7% yield. The inventive fagopyrum dibotry procyanidin extractive has a remarkable cough-relief and expectorant effect, which can be used for an effective component of the medicine.

Description

technical field [0001] The invention relates to a process for extracting proanthocyanidins from Chinese medicine golden buckwheat, which belongs to the technical field of Chinese herbal medicine extraction chemistry and chemical industry. Background technique [0002] Wild golden buckwheat (Fagopyrum dibotrys) is a perennial herbaceous plant of the genus Buckwheat in the Polygonaceae family. It is a resource plant with rich nutrition and important medicinal value. It has been listed as a national second-class protected plant in China. Modern research has confirmed that the main active ingredient contained in the rhizome of golden buckwheat is a mixture of proanthocyanidins, including barley catechin, proanthocyanidin B-2, B-4, and 3,3'-digallate of proanthocyanidin B-2. Proanthocyanidin substances are polymerized by different numbers of flavan-3-ols or flavan-3,4-diols, and 2-4 polymers are called oligomeric proanthocyanidin Oligomers (OPC). [0003] Proanthocyanidin molecu...

Claims

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Application Information

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IPC IPC(8): C07D311/62C07D311/60C07H17/07A61K31/352A61K31/7048A61P11/10A61P11/14
Inventor 吕敬慈雍克岚陆伟华陈旭
Owner SHANGHAI UNIV
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