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Hydroxypropyl beta-cyclodextrin clathrate of astaxanthin, and its preparing method

A technology of hydroxypropyl and cyclodextrin, which is applied in the field of preparation of inclusion compounds, can solve the problem of no obvious improvement in solubility, and achieve the effect of enhancing photothermal stability.

Inactive Publication Date: 2007-10-03
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The inclusion complex of β-cyclodextrin and astaxanthin has been reported in the literature (XiaolinChen, Rong Chen, Zhanyong guo, Cuiping Li, The preparation and stability of the inclusion complex ofastaxanthin with β-cyclodextrin.), the research results show that shrimp Penicillin can be included by β-cyclodextrin, and the photothermal stability of the formed inclusion complex is greatly improved, but the solubility is not significantly improved, and the solubility is less than 0.5mg / ml

Method used

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  • Hydroxypropyl beta-cyclodextrin clathrate of astaxanthin, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take hydroxypropyl-β-cyclodextrin, dry it to constant weight at 110°C, weigh 15g and place it in an Erlenmeyer flask, add 50ml of water and heat until the hydroxypropyl-β-cyclodextrin is completely dissolved, and continue to heat up to 70°C ( or 40°C, 80°C), and N into the Erlenmeyer flask 2 (or H 2 , CO 2 ) to protect the reactant from oxidation, dissolve 0.5g of astaxanthin with 5ml ethanol (or acetone), add to the dropping funnel, and drop into In the dextrin flask, continue to stir (or ultrasonic, reflux treatment) for 8 hours, concentrate the solution to 20ml under vacuum condition, after cooling to room temperature, place it in refrigerated overnight at 4°C, filter out the precipitate, and then place it in a 40°C refrigerator After drying in a vacuum oven for 4 hours, the hydroxypropyl-β-cyclodextrin inclusion compound of astaxanthin can be obtained, and the product is a lavender powder.

Embodiment 2

[0025] The clathrate powder obtained in Example 1 was first washed with ethanol (or acetone), then washed with water, and then vacuum-dried to obtain the hydroxypropyl-β-cyclodextrin clathrate of astaxanthin.

Embodiment 3

[0027] Mix 5g of hydroxypropyl-β-cyclodextrin with 10ml of pure water at room temperature, grind evenly, add 0.25g of astaxanthin solid powder, mix well, and grind (about 5 to 8 hours), the system consists of purple and white components When it turns into a uniform lavender paste, grind for 1 hour, and vacuum-dry at 40°C for 4 hours to obtain a fluffy lavender solid clathrate.

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Abstract

An inclusion compound of astaxanthin with hydroxypropyl-beta-cyclodextrin in mole ratio of 1: (1-100) features that part or all of astaxanthin moleculae are included in the cavities of hydroxypropyl-beta-cyclodextrin in order to improve the optical and thermal stability and water solubility of astaxanthin. It is prepared by deposition method, suspending method, or grinding method.

Description

technical field [0001] The present invention relates to a hydroxypropyl-β-cyclodextrin inclusion compound of astaxanthin and a preparation method of the inclusion compound. Background technique [0002] Astaxanthin widely exists in the biological world, especially in the feathers of shrimp, crab, fish and birds of aquatic animals. Astaxanthin is an important carotenoid, its chemical name is: 3,3-dihydroxy-4,4'-diketo-β-carotenoid, and its molecular formula (general formula) is: C 40 h 52 o 4 , molecular weight 596.86. Experiments have proved that astaxanthin is the only carotenoid that can pass through the blood-brain barrier. It has strong anti-tumor and antioxidant properties (10 times that of β-carotene and 500 times that of vitamin E), and can enhance the body's immunity , anti-hypertensive, control inflammation and other pharmacological effects. At the same time, astaxanthin is also a good coloring agent, which can improve the pigmentation of aquatic products, live...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/122A61K47/40A61P35/00A61P39/06A61K47/69
Inventor 陆亚鹏朱俐姜正林李建成
Owner NANTONG UNIVERSITY
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