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Open-pored polyurethane foam without skin formation, formulation for the production thereof and use thereof as a carrier material for cell and tissue cultures or medicaments

A technology of polyurethane foam and formulation is applied in the field of formulation of open-cell polyurethane foam to achieve good hydrophilic effect

Inactive Publication Date: 2007-10-17
POLYMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this requires another step of the method and, in addition, especially for medical applications such as tissue engineering, this may produce undesired filler residues still in the polymer with significant disadvantages

Method used

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  • Open-pored polyurethane foam without skin formation, formulation for the production thereof and use thereof as a carrier material for cell and tissue cultures or medicaments
  • Open-pored polyurethane foam without skin formation, formulation for the production thereof and use thereof as a carrier material for cell and tissue cultures or medicaments

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0056] 24% polycaprolactone diol (M n =1,250), 20% polycaprolactone triol (M n =900), 36% isophorone diisocyanate, 1.6% polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (M n =14,600), 4% triethanolamine, 0.08% water, 2.5% dextrose (equivalent to 3.9% based on polyol component containing all components except diisocyanate), 0.25% The formulation of diazabicycloundecene and 11.57% cyclohexane was thoroughly mixed at 60°C and then heated to 75°C for 4 hours in a petri dish. The resulting shaped articles have uniform porosity. Figure 2 clearly shows that the interconnectivity of the pores is well developed. In contrast to Comparative Example 1, in this case the pores are also open on the surface. After foam preparation, it was placed in boiling water for 1 hour to improve its hydrophilicity. They can then be easily loaded, for example, with a fibrin adhesive containing cell cultures such as chondrocytes, fibroblasts or osteoblasts.

example 2

[0058] The formulation as described in Example 1 was cast in a silicone mold with only one door. Silicone molds have been fabricated from stereolithographic models of the human ear. The mold was preheated to 70°C and this temperature was maintained for 8 hours for curing. A uniformly foamed shaped article is obtained. The pores are open on the surface and are interconnected with internal pores. In the case of such shaped articles, the hydrophilicity is also improved by boiling in water or saline. The shaped objects obtained can be easily filled with a mixture of cells, fibrin adhesive and various growth factors for the preparation of implants.

example 3

[0060] Example 3 demonstrates the suitability of the biocompatible nucleating agent tricalcium phosphate in the form of nanoparticles in formulations according to the invention.

[0061] Disperse 40% tricalcium phosphate nanoparticles as nucleating agent in polycaprolactone diol (M n =2000). A preparation containing 14.0% of the dispersion and 21.3% of polycaprolactone diol (M n =2,000), 21.3% polycaprolactone triol (M n =900), 17.7% isophorone diisocyanate, 1.8% polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (M n = 14,600), 2.1% triethanolamine, 0.07% water, 2.1% dextrose (equivalent to 2.55% based on polyol component including all components except diisocyanate), 1.4% The formulation of octanol, 0.21% diaminobicycloundecene and 18.02% cyclohexane was mixed thoroughly at 55°C and then heated to 75°C for 4 hours in a petri dish. The resulting shaped articles have uniform porosity. The pores are well interconnected and the pores are open on the su...

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PUM

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Abstract

The invention relates to a formulation for the production of a biocompatible, optionally bio-degradable, open-pored polyurethane foam which has open pores also on the surface thereof without any mechanical post-treatment, i.e.has no skin, a polyurethane form of said variety and a method for the production and use thereof. The invention also relates to a method for the production of a cell carrier for for cell cultures, tissue cultures and for tissue engineering, using the formulation for the production of the open-pored polyurethane foam, in addition to a cell carrier obtained by means of said method.

Description

technical field [0001] The invention relates to a formulation for the production of a biocompatible, optionally biodegradable open-cell polyurethane foam without a skin, which also has open pores on the surface without mechanical aftertreatment. The invention further relates to said polyurethane foam as well as to a process for its preparation and its use. The size of the pores of the polyurethane foam obtained by heating the formulation and the number of pores open towards the outside of the foam increase in those regions close to the surface of the foam. This enables the polyurethane foams of the invention to be used in the manufacture of scaffolds (cell supports) for cell culture, tissue culture and tissue engineering. Furthermore, the present invention relates to a method for the preparation of scaffolds for cell culture, tissue culture and tissue engineering using said formulation for the preparation of open-cell polyurethane foams and to the scaffolds for cell culture, ...

Claims

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Application Information

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IPC IPC(8): C08G18/32A61L27/38C08G18/64A61L27/50C08K5/1545A61L27/56
CPCA61L27/18A61L27/56C08G18/3218C08G18/6484C08K5/1545C08L75/04
Inventor 赫因利持·威斯哲哈特·迈尔
Owner POLYMATERIALS
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