18alpha- liquorice acid derivatives and preparation thereof

A technology of derivatives and glycyrrhizic acid esters, applied in the field of glycyrrhizic acid derivatives and their preparation, can solve the problems of low oral bioavailability and inconvenience to patients, and achieve good oral resistance to liver damage, excellent lipophilicity, and excellent bioavailability. degree of effect
CN101062937AActive Publication Date: 2007-10-31CHIA TAI TIANQING PHARMA GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHIA TAI TIANQING PHARMA GRP CO LTD
Publication Date
2007-10-31

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Abstract

The invention relates to a preparing method of glycyrrhizic acid derivant and usage.
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Description

technical field

[0001] The invention relates to glycyrrhizic acid derivatives and their preparation methods and uses, in particular to 18α-glycyrrhizic acid ester derivatives and their preparation methods and uses. Background technique

[0002] Glycyrrhizin (Glycyrrhizin, GC) is an effective active ingredient extracted from licorice. Its biological activity has been extensively studied at home and abroad and has been used clinically for many years. It has anti-inflammatory, anti-allergic, anti-biological oxidation, immune function regulation, block Ca 2+ Influx, dissociation of adrenal cortex hormone and stabilization of lysosomal membrane and other pharmacological effects, among which anti-inflammatory effect is the main mechanism of glycyrrhizic acid against liver injury.

[0003] Glycyrrhizic acid is a pentacyclic triterpene saponin, and the D / E ring in the glycyrrhizic acid triterpene component changes the direction of the C(17)-C(18) bond due to the obstruction of the ...

Claims

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