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Application of compound 6-furfuryl amino purine in preparing medicine for treating testis senility

A technology of furfuryl aminopurine and compound, which is applied in the application field of compound 6-furfuryl aminopurine for preparing anti-testicular aging drugs

Inactive Publication Date: 2007-11-07
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Now it is mostly used for plant anti-aging, fruit and vegetable preservation, and plant tissue culture. There are few studies on animal and human anti-aging, and the effect on the antioxidant capacity of aging animal testis has not been reported.

Method used

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  • Application of compound 6-furfuryl amino purine in preparing medicine for treating testis senility
  • Application of compound 6-furfuryl amino purine in preparing medicine for treating testis senility
  • Application of compound 6-furfuryl amino purine in preparing medicine for treating testis senility

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Experimental program
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Effect test

Embodiment Construction

[0014] 1 material

[0015] 1.1 Experimental animals

[0016] 30 Kunming mice, male. Weight 18 ~ 22g, purchased from the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0017] 1.2 Reagents

[0018] Compound 6-furfurylaminopurine, produced by Sanland Company of the United States, was prepared into a 2 g / L stock solution with 0.06 mol / L hydrochloric acid, and stored at 4°C for future use. D-galactose, produced by Sinopharm Chemical Reagent Co., Ltd., batch number F20050422. SOD detection kit (batch number 20061102), MDA detection kit (batch number 20061101), GSH-PX detection kit (batch number 20061101), NO detection kit (batch number 20061110) and Coomassie brilliant blue protein kit (batch number 20060323), all purchased from Nanjing Jiancheng Institute of Biology. Testosterone radioimmunoassay kit was purchased from Tianjin Jiuding Bioengineering Co., Ltd. (batch number 20061016).

[0019] 1.3 Main instruments

[0020] BS224S Sartorius analy...

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Abstract

The present invention discloses application of compound 6-furfuryl amino purine in preparing medicine for treating testis senility. It is proved by means of experiment that compound 6-furfuryl amino purine as one kind of exogenic purine matter can raise the antioxidase activity of the testis tissue of senile mouse, raise the ability of body's eliminating free radical, reduce the damage of cell caused by lipoid preoxidation, raise the antioxidant capacity of mouse's testis and raise the serum testosterone level of senile mouse, improve sex gland function and delay senility of sex gland.

Description

technical field [0001] The present invention relates to a new application of the compound 6-furfurylaminopurine (Kinetin, commonly known as kinetin), in particular to a new application of the 6-furfurylaminopurine for preparing anti-testicular aging drugs. Background technique [0002] In the aging process of the body, the hypogonadism is one of the important features. Gonadal aging in men is mainly closely related to the decline of hypothalamic-pituitary-gonadal axis function. Under normal circumstances, the hypothalamus-pituitary-testis coordinate with each other to maintain normal gonadal function. [0003] The hypothalamus regulates gonadal function through the pulse secretion of gonadotropin-releasing hormone (GnRH), the pacemaker point of GnRH pulse secretion formed by the GnRH neuron network, and the control of GnRH pulse release. GnRH burst pulse release causes pituitary LH pulse release, Bio-T feedback regulation inhibits the secretion of G...

Claims

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Application Information

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IPC IPC(8): A61K31/52A61K9/14A61K9/20A61K9/16A61K9/10A61K9/48A61K9/08A61P39/06A61P15/08A61P15/10
Inventor 欧阳五庆杨光敏
Owner NORTHWEST A & F UNIV
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