Bacterial packaging strains usefuel for generation and production of recombinant double-stranded RNA nucleocapsids and uses thereof

A technology of bacteria and strains, applied in the direction of bacteria, sugar derivatives, and vector-borne diseases, which can solve the problem of not providing recombinant fragment integration, not providing rdsRP composition, rdsRP replication and stable preparation, etc. question
CN101068919BActive Publication Date: 2011-08-10AERAS GLOBAL TB VACCINE FOUND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
AERAS GLOBAL TB VACCINE FOUND
Publication Date
2011-08-10

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Abstract

Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
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Description

field of invention

[0001] The present invention provides bacterial packaging strains suitable for producing recombinant double-stranded RNA nucleocapsids (rdsRNs), which can be used to produce RNAs encoding vaccine antigens, bioactive proteins, immunomodulatory proteins, antisense RNAs and catalytic RNA. In particular, the present invention also provides a bacterial packaging strain into which recombinant ssRNA can be introduced and packaged to form rdsRN in a de novo synthesis manner, and the rdsRN can be replicated in the packaging strain and thereby produce the target RNA. Background of the invention

[0002] Viral nucleocapsids, the nucleoprotein core of viruses, possess a number of features that make them valuable for expressing heterologous gene sequences in biological systems. Lacking the outer membrane and adhesins of intact viruses, nucleocapsids are noninfectious particles composed of the proteins and genetic material of the viral core, which retain the ability to...

Claims

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