Formulations of suberoylanilide hydroxamic acid and methods for producing same
A technology for suberoylanilide hydroxamic acid and suberoylanilide hydroxime, which is applied in the field of preparing the crystalline composition or pharmaceutical composition, and can solve the problems that DNA is difficult to achieve transcriptional regulatory elements and structures.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0073] The preparation of pharmaceutical compositions containing the active ingredients is well known in the art, for example by blending, granulating or tableting. The active therapeutic ingredient is often mixed with excipients which are pharmaceutically acceptable and compatible with the active ingredient. For oral administration, the active agent is mixed with the usual additives used for this purpose, such as carriers, stabilizers or inert diluents. And converted into suitable dosage forms for administration such as tablets as mentioned above, coated tablets, hard or soft gelatin capsules, aqueous, alcoholic or oily suspensions and the like by conventional methods.
[0074] In one embodiment, the oral compositions are formulated in dosage unit form for ease of administration and uniformity of dosage. Unit dosage forms as used herein are physically discrete units suited as unitary dosages for the treatment of individual subjects; each unit containing a predetermined quant...
Embodiment 1
[0242] Synthesis of SAHA Form I
[0243] The SAHA crystalline form can be synthesized according to the method outlined below or any modification and variation thereof
[0244] Synthetic SAHA
[0245] Step 1 - Synthesis of Octanoanilide
[0246]
[0247] 3,500 g (20.09 mol) of suberic acid was placed in a 22 L flask, and the acid was heated to melt. The temperature was raised to 175°C, and then 2,040 g (21.92 mol) of aniline were added. The temperature was raised to 190°C and held at this temperature for 20 minutes. The melt was poured into a Nalgene tank containing 4,017 g potassium hydroxide dissolved in 50 L of water. The melt was added and the mixture was stirred for 20 minutes. The reaction was repeated on the same scale and the second melt was poured into the same sodium hydride solution. After stirring the mixture well, the stirrer was turned off, and the mixture was left to stand. The mixture was...
Embodiment 1A
[0262] Preparation of SAHA Form I
[0263] Step 18 - Anilino-8-oxooctanoic acid; Octanoanilide acid (Compound 3)
[0264] Suberic acid (Compound 1, 174.2 g, 1.0 mol), aniline (Compound 2, 85.8-94.9 g) and toluene (0.1-0.2 L) were combined, heated to reflux, and refluxed for at least 60 hours. The reaction was quenched at reflux by adjusting the pH to >11 with 10% sodium hydroxide solution. The organic layer was combined with toluene (0.11-0.13 L) and water (0.3-0.4 L), and the aqueous layer was separated. The extracted aqueous layer was combined with toluene (0.11-0.13 L), separated into layers, and then separated. The aqueous layer was extracted twice with toluene (0.2-0.3 L) at 60-70°C. The aqueous layer was adjusted to pH 5.8-6.2 using hydrochloric acid and if necessary 10% sodium hydroxide solution at 20-30°C. The mixture was filtered, washed with cold water (0.2-0.3 L), then cold isopropanol. The wet cake was vacuum dried at a maximum of 65°C to obta...
PUM
| Property | Measurement | Unit |
|---|---|---|
| The average particle size | aaaaa | aaaaa |
| The average particle size | aaaaa | aaaaa |
| The average particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap