Ginkgo flavone and lactone dispersion tablet and preparation method thereof

A technology of ginkgo ketone esters and dispersible tablets, which is applied in the field of pharmaceuticals and can solve problems affecting the dissolution and absorption of lactones and flavonoids, and low dispersion of fine powders.

A technology of ginkgo ketone esters and dispersible tablets, which is applied in the field of pharmaceuticals and can solve problems affecting the dissolution and absorption of lactones and flavonoids, and low dispersion of fine powders.

CN101084890AInactive Publication Date: 2007-12-12BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Ginkgo ketone ester 40g calcium hydrogen phosphate 72g low-substituted hydroxypropyl cellulose 27.5g microcrystalline cellulose 9g aspartame 1.5g

[0026] The ginkgo ketone ester and the auxiliary materials in the prescription were pulverized into fine powder respectively, mixed uniformly by the method of equal increase, granulated with 60% ethanol in appropriate amount, dried, pressed into 1000 tablets, and the ginkgo ketone ester dispersible tablet was obtained.

Embodiment 2

[0027] Embodiment 2: Ginkgo ketone ester 22.5g pregelatinized starch 82.5g cross-linked polyvinylpyrrolidone 45g

[0028] The ginkgo ketone ester and the auxiliary materials in the prescription were pulverized into fine powder respectively, mixed uniformly by the method of equal increase, granulated with 40% ethanol in appropriate amount, dried, pressed into 1000 tablets, and the ginkgo ketone ester dispersible tablet was obtained.

Embodiment 3

[0029] Example 3: Ginkgo ketone ester 52.5g croscarmellose sodium 20g low-substituted hydroxypropyl cellulose 20g calcium sulfate 53g sodium saccharin 4.5g

[0030] The ginkgo ketone ester and the auxiliary materials in the prescription were pulverized into fine powder respectively, mixed uniformly by the method of equal increase, granulated with 80% ethanol in appropriate amount, dried, pressed into 1000 tablets, and the ginkgo ketone ester dispersible tablet was obtained.

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Abstract

The invention relates to a gingko ketonic ester dispersible tablet and its preparation method, and belongs to the field of Chinese traditional medicine. The tablet mainly comprises gingko ketonic ester and proper adjuvant. The inventive preparation has effects in activating blood circulation, dispelling blood stasis, and dredging meridians. The inventive dispersible tablet has improved water solubility and can rapidly disinregrate in cold water and form uniform suspensoid liquid. It has various administration manner including direct drink, direct deglutition, sublingual administration. It has convenient administration, high bioavailability, good taste, easy acceptability, rational and feasible technology, and stable and controllable quality.

Description

technical field [0001] The invention relates to a ginkgo ketone ester dispersible tablet for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases are the number one killer of human health, and have the characteristics of high morbidity, high mortality, and high disability rate. . According to reports, 2.6 million people die from cardiovascular and cerebrovascular diseases in my country every year, and one person dies from such diseases every 12 seconds. Therefore, prevention and treatment of cardiovascular and cerebrovascular diseases have become a serious and arduous task before us. topic. In this battle against cerebral ischemic injury, Ginkgo biloba preparations have emerged and attracted worldwide attention. With the continuous development of medicine and chemical industry, ginkgo ketone ester, the main active ingred...

Claims

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Application Information

Patent Timeline
12 Dec 2007
Publication
CN101084890A
IPC
A61K31/365; A61K36/16; A61K9/20; A61K47/32; A61K47/38; A61P9/10
Inventors
张保献