Method for preparing extractive of pubescent angelica root coumarin

A technology of extracts and cloves, which is applied in the field of preparation of cloves extracts, to achieve the effect of saving process steps, short production cycle, and reducing invalid impurity components

Inactive Publication Date: 2007-12-26
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problems existing in the existing literature on the extract of lovage, taking into account the content of the active ingredient coumarin in the extract of lovage and the needs of large-scale production of the extract, and proposes a patent for the invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Grind the lovage herb into coarse powder, pass through a 20-mesh sieve, extract 3 times with 6 times the amount of 90% ethanol for 2 hours each time, combine the extraction solvent, recover the solvent under reduced pressure, and obtain the extract A. After fully dispersing the extract A with 1 times the amount of water, shake and extract 3 times the amount of petroleum ether, extract 3 times, combine the extracts, concentrate under reduced pressure to a small volume (0.8 times the amount of the extract), and store at -4 Stand still at ℃, precipitate crystals, filter, and vacuum-dry to obtain the lovage extract. The detected total coumarin content is 65.33%.

Embodiment 2

[0022] Grind the lovage medicinal material into coarse powder, pass through a 20-mesh sieve, extract twice with 8 times the amount of methanol, each time for 2 hours, combine the extraction solvent, recover the solvent under reduced pressure, and obtain the extract A. After fully dispersing the extract A with 1 times the amount of water, shake and extract 1 times the amount of petroleum ether: ethyl acetate (99:1), extract 3 times, combine the extracts, concentrate under reduced pressure to a small volume (1 double amount), stand still at a temperature of -3°C, precipitate crystals, filter, and vacuum-dry to obtain the lovage extract. The detected total coumarin content is 61.23%.

Embodiment 3

[0024] Grind the lovage herb into coarse powder, pass through a 20-mesh sieve, extract 3 times with 10 times the amount of 90% ethanol or methanol for 2 hours each time, combine the extraction solvent, recover the solvent under reduced pressure, and obtain the extract A. After fully dispersing the extract A with 1 times the amount of water, shake and extract 1 times the amount of petroleum ether: ethyl acetate (98:1), extract 4 times, combine the extracts, concentrate under reduced pressure to a small volume (1.5% of the extract). times the amount), stand still at a temperature of -4°C, precipitate crystals, filter, and vacuum-dry to obtain the lovage extract. The detected total coumarin content is 60.78%.

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Abstract

The present invention relates to a preparation method of pubescent angelica root extract. It is characterized by that it adopts reflux extraction and liquid-liquid extraction process to prepare pubescent angelica root extract. In its extract the total coumarin content is above 50%.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract. More specifically, it is a preparation method of lovage extract. Background technique [0002] Duhuo is a commonly used traditional Chinese medicine, which was first recorded in "Shen Nong's Herbal Classic". Pharmacological tests have the effects of analgesia, sedation, and vasoconstriction. Clinically, it is mainly used to treat wind-cold-damp arthralgia, waist and knee pain, Shaoyin Fufeng headache, etc. The main chemical component of unihuo is coumarin, including dihydrocolumbianetin, columbianetin acetate, columbianadin, osthol, etc. Pharmacological experiments have proved that dihydro-piscereol, dihydro-piscereol acetate, dihydro-piscereol, methoxyparseirin, etc. have obvious inhibitory activity on rat platelet aggregation in vitro, can prolong the tail bleeding time of small white rats, and regulate the heart rate. Vascular function. There are many report...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61P29/00A61K125/00
Inventor 栾立标吴雅娜
Owner CHINA PHARM UNIV
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