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Surface modified microballons of containing phosphazene, and preparation method

A surface modification and microsphere technology, which is applied in chemical instruments and methods, catalyst carriers, physical/chemical process catalysts, etc., to achieve the effects of simple operation, environmental friendliness, and good biodegradability

Inactive Publication Date: 2007-12-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But even so, at least a two-step preparation process is required to obtain modified microspheres containing active groups by this method

Method used

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  • Surface modified microballons of containing phosphazene, and preparation method
  • Surface modified microballons of containing phosphazene, and preparation method
  • Surface modified microballons of containing phosphazene, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In a 500 ml flask, 1.08 g (4.32 mmol) of 4,4'-dihydroxydiphenylsulfone was dissolved in 250 ml of acetone, wherein the concentration of 4,4'-dihydroxydiphenylsulfone was 0.0043 g / ml; Add 0.87 g (8.64 mmol) of acid-binding agent triethylamine to the above reaction system; under the condition of 25° C., under the action of 100 W ultrasound, slowly add 30 ml of hexachlorocyclotriphosphazene with a concentration of 0.1 g / ml The acetone solution was added dropwise to the above system and reacted for 2 hours. After the reaction, the crude product was obtained by centrifugal separation, washed three times with acetone and then three times with deionized water, and then dried in a vacuum oven for 24 hours to obtain 0.64 g of surface-modified microspheres containing phosphazene.

[0020] Fig. 1 is the field emission scanning electron microscope photo of the phosphazene-containing surface-modified microspheres obtained in Example 1. It can be seen from the photo that the diameter...

Embodiment 2

[0024] In a 500 ml flask, 1.08 g (4.32 mmol) of 4,4'-dihydroxydiphenylsulfone was dissolved in 250 ml of acetone, wherein the concentration of 4,4'-dihydroxydiphenylsulfone was 0.0043 g / ml; Add 0.87 g (8.64 mmol) of acid-binding agent triethylamine to the above-mentioned reaction system; under the condition of 25°C, under the action of magnetic stirring, slowly add 30 ml of hexachlorocyclotriphosphazene with a concentration of 0.1 g / ml The acetone solution was added dropwise to the above system and reacted for 2 hours. After the reaction, the crude product was obtained by centrifugal separation, washed three times with acetone and then three times with deionized water, and then dried in a vacuum oven for 24 hours to obtain 0.56 g of surface-modified microspheres containing phosphazene. The diameter of the microsphere is 1.0-1.2 microns, and the specific surface area is 11.7 meters 2 / gram. Spectrum analysis shows that its structure is the cross-linked condensation structure ...

Embodiment 3

[0026] Using the equipment and preparation process described in Example 2, except that mechanical stirring was used for external field action, 0.61 g of hydroxyl-modified microspheres was obtained. The diameter of the microsphere is 1.1-1.5 microns, and the specific surface area is 10.4 meters 2 / gram. Spectrum analysis shows that its structure is the cross-linked condensation structure of hexachlorocyclotriphosphazene and 4,4'-dihydroxydiphenyl sulfone.

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Abstract

This invention discloses a method for preparing surface-modified microspheres containing phosphazene, whose chemical structure in shown in this invention. The diameters of the microspheres are 0.3-2.0 mu.m, and the specific surface areas are 10-30 m2 / g. The method comprises: condensing hexachlorocyclotriphosphazene and 4, 4'-dihydroxy diphenyl sulfone in the presence of an acid binding agent to obtain crosslinked microspheres. The method is simple, and suitable for mass production. The obtained microspheres can be used in controlled release of drugs, high-efficiency catalyst carriers, novel electric materials, novel optical materials, and flame retardant materials.

Description

Technical field: [0001] The invention relates to a polymer microsphere and a preparation method thereof, in particular to a surface-modified microsphere containing phosphazene and a preparation method thereof. Background technique: [0002] Polymer microspheres have been favored by more and more people because of their large specific surface area, good monodispersity, easy preparation and modification, adjustable biocompatibility, and beneficial for the study of interactions with biological components. Note that especially the application in the field of biomedicine has attracted much attention. Common pharmaceutical preparation microspheres can improve drug stability and bioavailability, reduce drug gastrointestinal irritation, and prolong drug action time. Appropriately modifying its surface to make it have a targeting effect is of great significance for improving the curative effect and reducing adverse reactions. Therefore, the preparation of surface-modified microsphe...

Claims

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Application Information

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IPC IPC(8): C08G79/02A61K47/34B01J32/00C09K21/14C08G79/025
Inventor 朱䶮黄小彬唐小真
Owner SHANGHAI JIAO TONG UNIV
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