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Devices and methods for interfacing microfluidic devices with fluid handling devices

A fluid handling and microfluidics technology, applied in chemical instruments and methods, fluid controllers, laboratory containers, etc., can solve problems such as pollution, connection complexity, and large consumption costs to the system, and achieve miniaturization replication. Cost, effect of minimizing post-processing operations

Inactive Publication Date: 2007-12-26
斯平克斯公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0018] A common problem in the production of microfluidic devices lies in the fact that the inputs that are often required to load fluids into the device must be fabricated using different methods than those used in microfabrication operations.
The complexity of the connection makes this scheme impossible for high-throughput liquid loading, since each chip must be fully connected to the loading device before use
Tube contamination is a major problem, and its systematic replacement would imply substantial consumable costs and additional input to the system

Method used

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  • Devices and methods for interfacing microfluidic devices with fluid handling devices
  • Devices and methods for interfacing microfluidic devices with fluid handling devices
  • Devices and methods for interfacing microfluidic devices with fluid handling devices

Examples

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example 2

[0145] Turning to FIG. 11 , an automated extraction scheme for removing tiles is shown. In a first example embodiment, selected microfluidic tiles 1112 in brick 1102 are selected to be extracted by a linear motion of plate 1101 . In this illustrative example, only brick 1102 is accessed by the drawer. Those skilled in the art will understand that this disassembly process can be applied to multiple bricks 1102 sequentially or in a desired order in one machine or in a production line. This type of automation is an efficient solution considering high throughput or unattended production lines ranging from compound loading, reagent dispensing, protocol running and assay readout. The production line can consist of a rail or belt driven mechanism assembly in which bricks 1102, with or without reagents, are fed into the slots of the conveyor, while continuous flow experiments can pass through conveyor "branches", tile withdrawal, redistribution and brick processing can be performed ...

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Abstract

The present invention is directed generally to devices and methods with the purpose of interfacing microfluidic devices with dispensing and fluid handling systems. Specifically, the present invention consists in the design of the inlets of a microfluidic device in such a way that multiple units can be loaded as a single compact device, with a unitary interface format which is compatible with existing industry standards.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 60 / 598,598, filed August 4, 2004, the entire contents of which are incorporated by reference. technical field [0003] The present invention relates to the field of microfluidic circuits for chemical, biological and biochemical processes or reactions. More specifically, the present invention discloses devices and methods for interfacing microfluidic devices with fluid handling devices. Background technique [0004] In recent years, pharmaceutical, biotechnology, chemical and related industries have increasingly adopted devices containing microchamber and channel structures for performing various reactions and analyses. These devices, commonly referred to as microfluidic devices, allow reducing the amount of reagents and samples required to perform an assay. They also enable a large number of reactions to occur in parallel or sequentially...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L2400/0409B01L2300/0816B01L2300/0829G01N2035/00237G01N35/028G01N2035/00326B01J2219/0081B01L2300/021B01L3/5025G01N2035/0425B01J19/0093B01L2200/028B01L2200/027B01L3/502707B01L2300/0861B01J2219/00891B01L9/527B01L3/502715
Inventor 皮耶罗・祖凯利蒂洛・卡伦巴赫吉安－卢卡・莱蒂耶里赫尔穆特・梅特伊莎贝尔・塞马可巴尔特・范德维维尔赫维・维奥兰
Owner 斯平克斯公司
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