20(R)-ginsenoside composition and uses thereof

A technology of ginsenoside and composition, applied in the application field of medicine or health care product, can solve the problems of easy recurrence, lack of specificity of cytotoxicity, cell damage and the like

Inactive Publication Date: 2008-02-06
DIHON PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of cancer chemotherapy is to kill tumor cells through chemical drugs, promote the death of tumor cells or prevent their proliferation, but the cytotoxicity of most chemical drugs lacks specificity. Especially hematopoiet...

Method used

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  • 20(R)-ginsenoside composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: capsule preparation

[0039] Weigh 20(R)-ginsenoside Rg 3 61.2 g, 20(R)-ginsenoside Rh 2 39.75 grams and 26.25 grams of ginsenoside III, add 867.8 grams of starch, mix well, sieve, use ethanol aqueous solution as binder to make a suitable soft material, granulate with 18 mesh sieve, dry in an oven at 60°C for 5 hours, 16 mesh Sieve the whole grain, add 5 grams of magnesium stearate, mix well, and make 1000 grains.

Embodiment 2

[0040] Embodiment 2: tablet preparation

[0041] Weigh 20(R)-ginsenoside Rg 3 75.3 g, 20(R)-ginsenoside Rh 2 29.25 grams and 24.75 grams of ginsenoside III, add 865.7 grams of starch, mix well, sieve, use ethanol aqueous solution as binder, make suitable soft material, granulate with 18 mesh sieve, dry in 60 ℃ oven for 5 hours, 16 mesh Sieve the whole grain, add 5 grams of magnesium stearate, mix well, and press into 1000 tablets.

Embodiment 3

[0042] Embodiment 3: preparation for injection

[0043] Weigh 20(R)-ginsenoside Rg 3 0.385 g, 20(R)-ginsenoside Rh 2 0.155 gram and 0.195 gram of ginsenoside III, add the propylene glycol of 20ml n-butanol and 30ml and make saponin dissolve completely, join the citric acid of 0.15 gram tetracaine hydrochloride, 0.02 gram in 40ml water for injection, make dissolving completely, and Add the above aqueous solution into the drug solution and mix well; adjust the pH value to 5.5±1.0 with borax and boric acid; add 0.1% activated carbon for needles and keep warm at 85°C for 30 minutes, filter with G3 vertical fused glass funnel, 0.22μm microporous filter membrane Filtrate; the filtrate is divided into 7ml vials, each with a volume of 2ml (the divided injections can be directly plugged and aluminum capped into injections; or freeze-dried by a freeze dryer to make freeze-dried powder injections).

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Abstract

The invention relates to a combination made of 20(R)-ginsenoside taken serving as active constitutent and the application of the combination as medicine or health products. The 20(R)-ginsenoside combination mainly comprises the following weight percentage compositions of the components: 30 percent to 60 percent of 20(R)-ginsenoside Rg3, 10 percent to 40 percent of 20(R)-ginsenoside Rh2 and 10 percent to 30 percent of ginsenoside III, wherein the ginsenoside III is 20(R)-protopanoxadiol-3-O-beta-pyrane xylopyranosyl (1-2) beta-D-pyrane glucosyl (1-2) beta -D-pyrane glucoside. The invention relates to application of the drug combination in preparing anticancer aided drug for preventing and curing leucocyte reduction caused by radiotherapy and chemotherapy and in medicine or health products improving human body immunity.

Description

technical field [0001] The invention relates to a composition composed of 20(R)-ginsenoside as an active ingredient, and the application of the composition as medicine or health product. Background technique [0002] Cancer is one of the three major diseases that endanger human health, and its morbidity and mortality have risen to the first place in some countries. Therefore, the development of anticancer drugs is one of the major issues faced by the majority of medical workers. Although many anti-cancer drugs that have been successfully developed at present have good therapeutic effects, their clinical application is limited due to the high toxicity and side effects of the drugs themselves. Therefore, the current research on anticancer drugs, on the one hand, continues to search for drugs that kill cancer cells to enhance the efficacy of anticancer drugs, and on the other hand, to find auxiliary anticancer drugs that reduce the toxic and side effects of anticancer drugs. ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P35/00A61P37/02
Inventor 周家礽汪伯良陈植和沈勇黄晓东
Owner DIHON PHARMA GROUP
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