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Sodium hydrogen carbonate injection plastic package and production method thereof

A sodium bicarbonate and plastic packaging technology, applied in the field of pharmaceutical packaging, can solve the problems of sodium bicarbonate injection pH value change, poor gas barrier performance, etc., and achieve the effect of facilitating production and ensuring stability

Inactive Publication Date: 2008-02-06
HUNAN CHINASUN PHARMA MASCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] If plastic bottles (bags) are used to pack sodium bicarbonate injection, since the plastic material (mainly polypropylene) used in the plastic bottles (bags) has poor gas barrier properties, the carbon dioxide decomposed from the aqueous solution of sodium bicarbonate The gas will seep out of the bottle (bag), and when the carbon dioxide gas in the bottle (bag) is lost, the aqueous solution of sodium bicarbonate in the bottle (bag) will decompose, causing the pH value of the sodium bicarbonate injection to change
[0007] Therefore, only glass bottles can be used at present, and plastic packaging cannot be used as packaging for liquid substances such as sodium bicarbonate injection.

Method used

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  • Sodium hydrogen carbonate injection plastic package and production method thereof
  • Sodium hydrogen carbonate injection plastic package and production method thereof
  • Sodium hydrogen carbonate injection plastic package and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] First make the plastic bottle 1 as shown in Figure 2; After the plastic bottle is cleaned, the sodium bicarbonate injection 3 prepared is poured in the plastic bottle 1; Fill the carbon dioxide gas 4 while filling the medicinal liquid, As shown in Figure 3; The plastic bottle that filling medicinal liquid and be full of carbon dioxide gas 4 is sealed with combination cap 12 afterwards, as shown in Figure 4; In the protective bag 2, and before sealing, the air in the bag is drawn out and filled with carbon dioxide gas 5, as shown in Figure 1; Packing can be done after passing the test.

Embodiment 2

[0061] First make the plastic inner bag 6 as shown in Figure 6; Fill the sodium bicarbonate injection 3 prepared in the plastic inner bag 6; Fill into carbon dioxide gas 4 while filling the medicinal liquid, as shown in Figure 7 ; Use combination cover 12 to be filled with liquid medicine and be full of the plastic inner bag 6 sealing of carbon dioxide gas 4 afterwards, as shown in Figure 8; Protect the bag 2, and before sealing, the air in the bag is drawn out and filled with carbon dioxide gas 5, as shown in Figure 5; the package shown in Figure 5 is sterilized at high temperature, and then the sterilized product is passed the light inspection Then pack it.

Embodiment 3

[0063] First make the plastic bottle 1 shown in Figure 2; after the plastic bottle is cleaned, pour the sodium bicarbonate injection 3 prepared in the plastic bottle 1; fill the carbon dioxide gas 4 while filling the medicinal liquid 3; use combination cover 12 to be filled with medicinal liquid and be full of the plastic bottle of carbon dioxide gas 4 to seal afterwards, as shown in Figure 4; Plastic bottle shown in Figure 4 is carried out high-temperature sterilization; Plastic after sterilization The bottle is sealed in a protective bag 2 made of a high gas barrier film, and before sealing, the air in the bag is drawn out and filled with carbon dioxide gas 5, as shown in Figure 1. Pack the product as shown in Figure 1 after passing the light inspection.

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Abstract

The invention discloses a sodium bicarbonate injection plastic package and the manufacturing method, wherein the plastic package comprises first containers (1, 6) containing sodium bicarbonate injection (3) and charged with first carbon dioxide gas (4) and a second container (2) made from gas-barrier material; the first containers (1, 6) are sealed inside the second container (2). The manufacturing method comprises the following steps: the first containers (1, 6) are provided and the sodium bicarbonate injection (3) is filled in the first containers (1, 6); the first carbon dioxide gas (4) is charged into the first containers (1, 6) and then the first containers (1, 6) is sealed; the second container (2) made from gas-barrier material is provided and the sealed first containers (1, 6) are arranged inside the second container (2); and then, the second container (2) is sealed. The plastic package of the invention can guarantee that the sodium bicarbonate injection contained therein does not decompose.

Description

technical field [0001] The invention belongs to the field of medical packaging, in particular to a plastic packaging of sodium bicarbonate injection and a production method thereof. Background technique [0002] In the field of pharmaceutical packaging, plastic packaging has been widely used for its good stability and low cost. [0003] However, some liquid medicines can only be packaged in glass bottles because glass bottles have high gas barrier properties. Taking the commonly used sodium bicarbonate injection as an example, because sodium bicarbonate injection is easily decomposed into sodium carbonate, carbon dioxide and water during storage, if this happens, the pH value of sodium bicarbonate injection will change, such as injection When it enters the human body, it will cause the pH value of the body fluid to be disturbed. The equation for the decomposition of aqueous sodium bicarbonate solution is: [0004] [0005] It can be seen from the above formula that the...

Claims

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Application Information

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IPC IPC(8): B65D77/04B65D81/20B65D41/28B65D65/38B65D65/40A61J1/05A61J1/14B65B31/04B65B55/02
Inventor 刘祥华彭勋德
Owner HUNAN CHINASUN PHARMA MASCH CO LTD
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