Photochromic intraocular lens

An intraocular lens and photochromic technology, applied in the direction of intraocular lens, optics, optical components, etc., can solve the problems of the wearer of the intraocular lens, such as obstacles and reduced vision

Inactive Publication Date: 2008-02-20
IOLTECH PRODN
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, these intraocular lenses have the disadvantage of reducing vision when the brightness is low.
T

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Photochromic intraocular lens
  • Photochromic intraocular lens
  • Photochromic intraocular lens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1: 8-Hydroxymethyl-3,3,diphenyl-3Hnaphtho[2,1]-pyran (compound (4)) Synthesis

[0093] This example is provided with reference to Synthesis Scheme n°1 above.

[0094] step 1 : Esterification of compound (1)

[0095] In a three-necked flask (250 ml) placed on a condenser, compound (1) (7 g) was dissolved in 80 ml of methanol. The esterification reaction was catalyzed by the addition of p-toluenesulfonic acid (APTS, 0.48 g), which was introduced under nitrogen. The reaction was brought to a temperature of 70°C and kept stirring for at least 12 hours.

[0096] At the end of this period, methanol was evaporated and the remaining organic phase was dissolved in ethyl acetate for liquid / liquid extraction (ethyl acetate / potassium carbonate saturated water) in order to purify the desired ester (compound (2)) .

[0097] The organic phase obtained by different washings was subsequently washed in MgSO 4 dried and then filtered. Evaporation of ethyl acetate allowe...

Embodiment 2

[0106] Example 2: Functionalization with Acryloyl Chloride: Compound (5)

[0107] In a three-necked flask (100ml) placed on the condenser, 1g of compound (4), 0.5ml of Et dissolved in 30ml of anhydrous THF were introduced 3 N (1.3 eq / (4)), addition of chloride was done dropwise in the presence of nitrogen at ambient temperature, no significant temperature increase was observed. The reaction was kept at ambient temperature with stirring for at least 12 hours.

[0108] At the end of this cycle, the solvent is evaporated. The residue was diluted in dichloromethane and extracted with successive washes of water saturated with potassium carbonate. Extract the organic phase using MgSO 4 Dry, filter on silica and solvent evaporated.

[0109] 3,3 Diphenyl-3Hnaphtho[2,1]-pyranacrylate was isolated in 60% mass yield.

Embodiment 3

[0110] Example 3: Functionalization with methacryloyl chloride

[0111] The synthesis was identical to that described in Example 2, except that methacryloyl chloride was substituted for acryloyl chloride.

[0112] 3,3Diphenyl-3Hnaphtho[2,1]-pyranylmethacrylate is thus obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an intraocular lens comprising at least one pharmaceutically-acceptable photochromic polymer that enables all or part of the intraocular lens to change colour reversibly when exposed to light.

Description

technical field [0001] The present invention relates to hydrophilic or hydrophobic soft or hard capsular intraocular lenses at least partly composed of copolymers having photochromic monomer units so that when exposed to light (such as ultraviolet light) the implant or Part of it reversibly changes color. Background technique [0002] The lens is the lens contained in a bag called the capsular bag at the back of the iris. A cataract is a clouding of the lens. [0003] Known cataract surgery is to incise a large portion of the front wall of the anterior capsule called the capsular bag and remove the lens therefrom. The removed lens is then replaced with an intraocular lens in the capsular bag. [0004] The intraocular lens may take the form of a so-called "hard" implant or a so-called "soft" implant. [0005] So-called "soft" implants have the advantage of being easier to fix and stabilize in the capsular bag than hard implants. [0006] Soft implants generally consist o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G02B1/04G02B5/23A61L27/16C07D311/92
CPCA61F2/1659G02B1/043A61L2430/16C08L33/10C08L33/08
Inventor P·贝纳德M·多拉哈尼A·帕纽C·于佩因
Owner IOLTECH PRODN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap