Diclofenac or the salt partial film forming gel composition and uses thereof

Abstract

The present invention discloses a compound of an diclofenac or the halo-diclofenac local membrane forming gel, which comprises the components of the following weight percentages comprising 0.5 percentage to 7 percentage of alkyl cellulose, 1 percentage to 10 percentage of etherifying agent , 0.5 percentage to 5 percentage of cross linking agent, 75 percentage to 90 percentage of dissolvent, 0.1percentage to 3 percentage of diclofenac or the halo-diclofenac. The cross linking agent is the saturated fat or the alcoholic acid, the chemical general formula of which is CnH2n+2-m-l(OH)m(COOH)l. Among the formula, m or n or 1 is the integer and the n is no less than m, which is no less than 2. 1 is no less than 0 and the result of m plus 1 is 4 to 8. The result of n plus 1 is 4 to 8. In the present invention, the compound of the diclofenac or the halo-diclofenac local membrane forming gel is applied for relieving the local pain and inflammation of the organism tissue. A water drain protective membrane with smooth property, firm property, wear-resisting property and duration property is formed on the surface of the ulcer when the present invention is applied. Compared with all kinds of formulations of the diclofenac or the halo-diclofenac in the present technique, the membrane formed by the gel compound is not likely to experience fracture, dissolution or corrosion. The membrane has properties of long maintenance time and slow releasing of the medicine.

Description

technical field [0001] The invention relates to a local film-forming gel composition which uses diclofenac or its salt as a pharmaceutical active ingredient and its application in alleviating local tissue pain and inflammation of the body. Background technique [0002] Local bone and soft tissue inflammation, such as tenosynovitis, shoulder-hand syndrome and bursitis, periarticular lesions, osteoarthritis of extremities and spine; post-traumatic inflammation of tendons, ligaments, muscles and joints, such as sprains, strains and contusions; And various pains are common symptoms and diseases in people's daily life. The topical pharmaceutical preparations clinically used to treat these diseases are usually non-steroidal anti-inflammatory analgesics, such as diclofenac (Diclofenac acid) and its salts, such as diclofenac sodium (Diclofenac Sodium), diclofenac potassium (Diclofenac Potassium), Diclofenac Diethylammon (Dichofenac Diethylammon) and the like are emulsions, gels, li...

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture prematurely, fall off, and even disappear. Its effective residence time on the oral mucosa is only 3 to 4 hours, such as the film formed on the skin surface The membrane is easily eroded / dissolved by body fluids, causing the membrane to rupture and fall off prematurely, resulting in faster disappearance

[0007] Therefore, if the technology of the above-mentioned existing film-forming gel composition is used to prepare diclofenac or its salt local film-forming gel composition, then the medicament and the affected part will keep for a short time, which will affect the curative effect.

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