Tadalafil chewing gum and manufacturing method and application
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A tadalafil, chewing gum technology, applied in chewing gum, applications, pharmaceutical formulations, etc., can solve problems such as self-esteem and willpower damage, disharmony between husband and wife, and meaningless life
Inactive Publication Date: 2011-11-09
北京康业元投资顾问有限公司
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Abstract
Description
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Problems solved by technology
Although ED does not have a direct adverse effect on health, patients often have a lot of mental stress, self-esteem and willpower are greatly damaged, most people feel that life is meaningless, it is very easy to cause disharmony between husband and wife, and family breakdown. , and affect social stability, it has attracted great attention from the international medical community
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Embodiment 1
[0042] Tadalafil chewing gum, its composition comprises: chewing gum base, wherein contains tadalafil or tadalafil hydrochloride, citrate or lactic acid salt, the ratio of parts by weight is: chewing gum base 100: tadalafil Rafi 0.1-10.
[0043] The chewing gum base contains 5-30 parts of edible gum base, 15-40 parts of syrup with a content of 40-70% or 1-50 parts of sweetener, the above parts are parts by weight.
[0044] The syrup is sorbitol or glucose or corn syrup, and the sweetener is powdered sugar or mannitol or xylitol or other sweeteners.
[0045] The tadalafil or salt contained in each individually packaged tadalafil chewing gum (block or tablet) is 5-20 mg, one tablet each time.
Embodiment 2
[0047] Prescription: Each ingredient in this product is by weight (mg)
[0048] Tadalafil or tadalafil hydrochloride (calculated as tadalafil) 5mg
[0049] Edible gum base 1500mg
[0050] 45% syrup (containing sorbitol) 50mg
[0051] Carmine (pigment) 0.1mg
[0052] Powdered sugar (sweetener) 1000mg
[0053] Glycerin and Soy Lecithin (edible plasticizer) 1mg
[0054] Food flavor (strawberry flavor) 0.1mg
[0055] Gelatin (humectant, softener) 10mg
[0056] The tadalafil or salt contained in each individually packaged tadalafil chewing gum (block or tablet) is 5-20 mg, one tablet each time.
Embodiment 3
[0058] Sugar-free prescription: each ingredient in this product is by weight (mg)
[0059] Tadalafil hydrochloride (calculated as tadalafil) 25mg
[0060] Edible gum base 1000mg
[0061] 45% syrup (containing sorbitol) 50mg
[0062] Carmine + Methylene Blue (Rose Pigment) 0.1mg
[0063] Sorbitol (sweetener) 500mg
[0064] Xylitol 50mg
[0065] Glycerin and Soy Lecithin (edible plasticizer) 1mg
[0066] Flavoring (spearmint and menthol) 0.1mg
[0067] Gelatin (humectant, softener) 10mg
[0068] The tadalafil or salt contained in each individually packaged tadalafil chewing gum (block or tablet) is 5-20 mg, one tablet each time.
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Abstract
A tadalafil chewing gum and the manufacturing method and the application relate to a medical chewing gum for remedying male sexual dysfunction and the preparation method. Because of the indissolubility and the low biological utilization degree of the tadalafil, the noneffective dosage is large, and a plurality of adverse reactions occurs. The component of the tadalafil chewing gum includes a chewing gum matrix, which contains tadalafil or tadalafil slat, and the ratio of the weight portion is 100 portions of chewing gum matrix to 0.1 to 10 portions of tadalafil. The product is used for improving the administration method of the drug of tadalafil for the male sexual dysfunction and can promote the stable absorption of the drug. The drug can be directly absorbed through the sublingual vein by orally chewing, which reduces the damage towards the drug because of gastrointestinal enzyme and liver enzyme (first-pass effect) and improves the biological utilization degree and reduces the dosage of the drug; the invention can also reduce the stimulation of the drug toward the gastrointestinal tract, which reduces the occurrence of the adverse reaction and increases the safety.
Description
Technical field: [0001] The invention relates to chewing gum as a medicine for treating male sexual dysfunction and a preparation method thereof, and the application of machine tadalafil in making chewing gum. Background technique: [0002] Male erectile dysfunction (erectiong disturbance, ED), commonly known as impotence. It is a common disease of adult men. With the continuous development of society and the increasing competition in society, people's rhythm of life and work pressure are also increasing, and its incidence is also showing an upward trend. According to statistics: the incidence of ED accounts for 40% in 40-year-old men, 50% in 50 years, 60% in 60 years and age changes with age, and the incidence of ED is also increasing. Although ED does not have a direct adverse effect on health, patients often have a lot of mental stress, self-esteem and willpower are greatly damaged, most people feel that life is meaningless, it is very easy to cause disharmony between hu...
Claims
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Application Information
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