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Medicinal composition capable of anti-senility during menopausal syndrome

A composition and anti-aging technology, applied in the directions of drug combination, antidote, pharmaceutical formula, etc., can solve the problem of no effective report of estrogen mechanism, and achieve the goal of delaying osteoporosis lesions, preventing osteoporosis, protecting The effect of the uterus

Active Publication Date: 2008-03-19
广州淡韵生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Soybean isoflavone treatment is still essentially an exogenous supplementary therapy that replaces estrogen, which can correct endocrine disorders and osteoporosis caused by estrogen decline to a certain extent, but has no effect on promoting estrogen production. Mechanism has no efficacy reports

Method used

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  • Medicinal composition capable of anti-senility during menopausal syndrome
  • Medicinal composition capable of anti-senility during menopausal syndrome
  • Medicinal composition capable of anti-senility during menopausal syndrome

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0100] 1. Preparation of each component in the active ingredient:

[0101] (1) Epimedium extract: Weigh the dry powder of the whole herb of Epimedium, add 10 times the amount of distilled water, heat to a slight boil for extraction for 30 minutes, cool, and coarsely filter; repeat the extraction of the filter residue once; combine the coarse filtrate twice, and suction filter . Take the pretreated D101 macroporous adsorption resin, pack it into a column by wet method, wash it with water and set it aside. The epimedium water extract was applied to a D101 resin column, the resin column was washed with 5 times the volume of distilled water, and then eluted with 3 times the volume of 50% ethanol. The solution eluted by the resin was extracted 3 times with chloroform (removing less polar impurities) and ethyl acetate for 3 times successively, and the consumption of each extractant was 2 times of the volume of the liquid to be extracted, and the ethyl acetate phases were combined. ...

example 2

[0111] 1. Preparation of each component in the active ingredient:

[0112] (1) Epimedium extract: Weigh the dry powder of the whole herb of Epimedium, then extract it with 10 times the volume of 70% ethanol under reflux, collect the reflux liquid, filter and recover the ethanol, concentrate and dry in a thin film rotary evaporator to obtain Epimedium Huskwort extract, which contains 20% of total flavonoids of Epimedium.

[0113] (2) Yam extract: Crush the yam decoction pieces to about 10 meshes, add an equal volume of 2% sulfuric acid and petroleum ether according to the ratio of raw medicinal material: 2% sulfuric acid = 1:12, hydrolyze at 90°C for 5 hours, pour out , cooling, layering, taking the upper layer (petroleum ether part), washing with sodium carbonate solution until neutral, then washing with distilled water, recovering petroleum ether, evaporating to dryness, washing with ethanol, recovering ethanol, evaporating to dryness, and placing in a vacuum at 70°C Dried t...

example 3

[0122] (1) Epimedium extract: Weigh the dry powder of the whole herb of Epimedium, add 10 times the amount of distilled water, heat to a slight boil for extraction for 30 minutes, cool, and coarsely filter; repeat the extraction of the filter residue once; combine the coarse filtrate twice, and suction filter . Put the Epimedium water extract on the D101 resin column (resin weighs 100g), wash the resin column with 5 times the volume of distilled water, then elute with 3 times the volume of 50% ethanol, concentrate to dryness under reduced pressure at 60 ° C, and extract the epimedium It contains 70% total flavonoids of Epimedium

[0123] (2) Chinese yam extract: crush the yam decoction pieces to about 10 meshes, add an equal volume of 2% sulfuric acid and petroleum ether according to the ratio of raw medicinal material: hydrolyzate = 1:10, hydrolyze at 88°C for 4 hours, pour out, Cool, separate layers, take the upper layer (petroleum ether part), wash with sodium carbonate so...

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Abstract

The invention provides an antiaging drug combination for the menopause. The combination consists of active components and medically acceptable complementary materials, wherein the active components consists of the components with the following weight portions of 10 to 31 portions of epimedium herb extracts, 21 to 70 portions of yam extracts and 20 to 50 portions of soybean isoflavone extracts, wherein the epimedium herb extracts contain 20 to 90 percent of total flavones of the epimedium herb; the yam extracts contain 20 to 60 percent of diosgenin; the soybean isoflavone extracts contain 10 to 60 percent of soybean isoflavones. The combination of the invention can protect the women uterus and prevent the osteoporosis and effectively delay the menopause aging of women.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a Chinese patent medicine prepared from traditional Chinese medicines. Background technique [0002] Menopausal syndrome is a group of syndromes accompanied by neuropsychological symptoms caused by the decline of ovarian function, estrogen level, and gonadotropin increase in women before and after menopause. Postmenopausal osteoporosis refers to osteoporosis caused by low estrogen levels after menopause, which usually occurs 5 to 10 years after menopause, and belongs to primary osteoporosis. It is characterized by a decrease in the proportion of bone mineral content and matrix components, thinning of the cortical bone, and reduction and thinning of the trabecular bone. Epidemiological research data show that: about 30% of postmenopausal women have osteoporosis. [0003] At present, there are estrogen drugs in the prevention and treatment of menopausal syndrome, but this type of drugs ha...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/20A61K9/48A61P15/12A61P39/06A61K31/352
Inventor 王剑
Owner 广州淡韵生物科技有限公司
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