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Meloxicam orally disintegrating tablets and method for preparing the same

An orally disintegrating tablet, meloxicam technology, applied in the directions of pill delivery, non-central analgesic, antipyretic, etc., can solve the problems of inconvenient taking, backward preparation process, slow drug dissolution, etc. The effect of solving difficulty in taking medicine and less intestinal residue

Inactive Publication Date: 2008-04-02
上海爱的发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, although meloxicam has various oral dosage forms, all of them have defects of varying degrees, such as inconvenient taking, slow drug dissolution, relatively backward preparation technology, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Meloxicam 100g

[0027] Mannitol 1200g

[0028] Cross-linked polyvinylpyrrolidone 150g

[0029] Aspartame 20g

[0030] Orange essence 12g

[0031] Polyvinylpyrrolidone 20g

[0032] Magnesium Stearate 12g

[0033] Pre-mix meloxicam raw materials with mannitol and partially cross-linked polyvinylpyrrolidone in a three-phase granulator; add polyvinylpyrrolidone 50% alcohol aqueous solution to the mixed powder in the previous step to granulate; pour out the wet granules and spread them on the tray , put it in an oven and dry at 60°C for 5 hours; sieve through a 26-mesh granule; pour aspartame, orange essence and remaining cross-linked polyvinylpyrrolidone and the granules obtained in the previous step into a three-dimensional mixer and mix for 30 minutes. Then add magnesium stearate and mix for 1-2 minutes; pour the mixed material into the hopper of the tablet press, adjust the tablet weight and pressure, press the tablet and keep the hardness of the tablet at 20-40N; ...

Embodiment 2

[0035] Meloxicam 100g

[0036] Mannitol 800g

[0037] Cross-linked polyvinylpyrrolidone 95g

[0038] Aspartame 15g

[0039] Orange essence 10g

[0040] Polyvinylpyrrolidone 15g

[0041] Magnesium Stearate 10g

[0042] Pre-mix meloxicam raw materials with mannitol and partially cross-linked polyvinylpyrrolidone in a three-phase granulator; add polyvinylpyrrolidone 50% alcohol aqueous solution to the mixed powder in the previous step to granulate; pour out the wet granules and spread them on the tray , and dried in an oven at 60°C for 4 hours. Sieve through a 26-mesh granule; pour aspartame, orange essence and remaining cross-linked polyvinylpyrrolidone and the granules obtained in the previous step into a three-dimensional mixer and mix for 30 minutes, then add magnesium stearate and mix for 1 to 2 minutes ; Pour the mixed material into the hopper of the tablet press, adjust the weight and pressure of the tablet, press the tablet and keep the hardness of the tablet at 20-...

Embodiment 3

[0044] Meloxicam 100g

[0045] Mannitol 1500g

[0046] Cross-linked polyvinylpyrrolidone 175g

[0047] Aspartame 25g

[0048] Orange essence 17g

[0049] Polyvinylpyrrolidone 25g

[0050] Magnesium Stearate 17g

[0051] Pre-mix meloxicam raw materials with mannitol and partially cross-linked polyvinylpyrrolidone in a three-phase granulator; add polyvinylpyrrolidone 50% alcohol aqueous solution to the mixed powder in the previous step to granulate; pour out the wet granules and spread them on the tray , placed in an oven and dried at 60°C for 7 hours; sifted through a 26-mesh granule; poured aspartame, orange essence and remaining cross-linked polyvinylpyrrolidone and the granules obtained in the previous step into a three-dimensional mixer and mixed for 30 minutes, Then add magnesium stearate and mix for 1-2 minutes; pour the mixed material into the hopper of the tablet press, adjust the tablet weight and pressure, press the tablet and keep the hardness of the tablet at 2...

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Abstract

The invention discloses a meloxicam orally disintegrating tablet, which is of reasonable formula and good vioavailability, and the preparation method. The content of the principal agent of the meloxicam orally disintegrating tablet, meloxicam, is 5 to 20 percent. The excipient contains disintegrant, diluent or binder, adhesive, sweetener, arom atic agent, lubricant, etc. The preparation method adopts modern preparation technology and the product has stable quality. So the preparation method provides patients with safe and effective meloxicam orally disintegrating tablet.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a meloxicam orally disintegrating tablet prepared by modern tablet technology and a preparation method thereof. Background technique [0002] Meloxicam is a new type of non-steroidal anti-inflammatory drug developed by Boehringer Ingelheim of Germany. It was launched in South Africa and the United Kingdom in 1996. Its dosage forms include tablets and suppositories. The greatest feature of meloxicam is the selective inhibition of type II cyclooxygenase (COX-2), which is mainly used for the treatment of rheumatoid arthritis and osteoarthritis, and can also be used for antipyretic and analgesic. Compared with the traditional non-steroidal anti-inflammatory drugs currently used, it has the advantages of strong anti-inflammatory effect, long-term anti-inflammatory pain effect, good antipyretic effect, and greatly reduces the gastrointestinal and renal side effects of non-ste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5415A61P29/00
Inventor 胡愈璋陈敏娟徐景朱雨秋
Owner 上海爱的发制药有限公司
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