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Pharmaceutical composition of cattail pollen and kudzu root

A composition, technology of kudzu root extract, applied in the field of medicine

Inactive Publication Date: 2011-08-31
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of the interaction between Pueraria Radix and Pueraria Radix to formulate prescriptions for the treatment of cardiovascular and cerebrovascular diseases.

Method used

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  • Pharmaceutical composition of cattail pollen and kudzu root
  • Pharmaceutical composition of cattail pollen and kudzu root
  • Pharmaceutical composition of cattail pollen and kudzu root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] The preparation of embodiment 1 Puhuang extract (with total flavonoids as main component)

[0101] 1. Preparation of Puhuang Extract

[0102] Take the medicinal material of Puhuang, add 70% ethanol to extract three times, and extract for 3 hours each time. Add alcohol 14 times the amount for the first and second times, add alcohol 10 times the amount for the third time. Combine the extracts, filter, recover ethanol from the filtrate to a relative density of 1.04-1.06 (50°C), add an equal amount of water to dilute, mix well, refrigerate at 4°C for 24 hours, centrifuge, take the supernatant, shake with an equal amount of petroleum ether Shake and extract twice, discard the petroleum ether solution, shake and extract the water solution three times with an equal amount of water-saturated n-butanol, combine the n-butanol extracts, concentrate to a thick paste, and spray dry to obtain the Puhuang extract.

[0103] 2. Determination of the content of Puhuang extract

[010...

Embodiment 2

[0112] The preparation of embodiment 2 kudzu root extract (with total flavonoids as main component)

[0113] 1. Preparation of kudzu root extract

[0114] Take Pueraria root medicinal material, pulverize, add 75% ethanol to heat and reflux for extraction 3 times, add 12 times the amount of alcohol for the first time, extract for 2 hours, add 10 times the amount of alcohol for the second time, extract for 2 hours, add 8 times the amount of water for the third time, Extract for 1.5 hours. Combine the extracts, filter, the filtrate is concentrated until it has no alcohol smell, filter, and the processed D on the filtrate 101 In the macroporous resin, elute with water, 15% ethanol, and 70% ethanol respectively, and the elution volume is 3 times the volume of the column. Collect 70% of the eluate, recover ethanol, and concentrate under reduced pressure to a relative density of 1.1-1.3 (50°C) and dried to obtain the kudzu root extract.

[0115] 2. Determination of Pueraria root...

Embodiment 3

[0124] Embodiment 3: the preparation of pueraria tablet

[0125] 1. Prescription:

[0126] Prescription 1

[0127] Puhuang 20g (equivalent to 1000g of raw medicinal materials)

[0128] Pueraria 60g (equivalent to 2000g of raw medicinal materials)

[0129] Starch 120.0g

[0130] Microcrystalline Cellulose 40.0g

[0131] 2% HPMC aqueous solution appropriate amount

[0132] Magnesium Stearate 2.0g

[0133] Sodium starch glycolate 4.0g

[0134] A total of 1000 tablets were prepared

[0135] Prescription 2

[0136] Puhuang 40g (equivalent to 2000g of raw medicinal materials)

[0137] Pueraria 120g (equivalent to 4000g of raw medicinal materials)

[0138] Starch 140.0g

[0139] Microcrystalline Cellulose 40.0g

[0140] 2% HPMC aqueous solution appropriate amount

[0141] Magnesium Stearate 2.0g

[0142] Sodium starch glycolate 4.0g

[0143] A total of 1000 tablets were prepared

[0144] Prescription 3

[0145] Puhuang 60g (equivalent to 3000g of raw medicinal mate...

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PUM

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Abstract

The present invention relates to medical technique field, to disclose a medicine composition for treating cardiovascular and cerebrovascular diseases, constitution of the raw materials used for preparing the medicinal composition containing the effective components are: cattail pollen and pueraria root or cattail pollen extraction and pueraria root extraction, and to disclose preparation containing the medicinal composition and its preparation method and application, the weight ratio range is: cattail pollen 1000 to 8000, pueraria root 2000 to 10000 or cattail pollen extraction 20 to 320, pueraria root extraction 60 to 500. The medicinal composition can be prepared into clinic or pharmaceutical acceptable preparations, optimizing oral preparation or injection. The medicinal composition ofthe present invention has synergistic interaction, and has better curative effect for cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, myocardial infarction, hypertension, hyperlipemia atherosclerosis, ischemic cerebrovascular disease and etc.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for cardiovascular and cerebrovascular diseases. The raw material medicine for making the medicinal components contained in it is composed of Puhuang and Pueraria Radix or Puhuang Extract and Pueraria Radix Extract, And provide its preparation method and preparation. [Background technique] [0002] Cardiovascular and cerebrovascular diseases are the most important diseases that endanger human life and health. According to relevant statistics in recent years, people who die from cardiovascular and cerebrovascular diseases account for about half of the cause of death in my country every year. Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, high blood pressure, hyperlipidemia, etc. The etiology is atherosc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61P9/10A61P9/12A61P3/06
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司