Nucleic acids, polypeptides, and methods for modulating apoptosis

A technology for apoptosis and cancer cells, applied in the fields of nucleic acid, polypeptide, and regulation of cell apoptosis, which can solve the problems of normal cells having little effect and failing to occur in time.
CN101164624BInactive Publication Date: 2011-01-26SENESCO TECHNOLOGIES INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SENESCO TECHNOLOGIES INC
Publication Date
2011-01-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a nucleic acids, polypeptides, and methods for modulating apoptosis. The present invention relates to isolated and / or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
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Description

[0001] This application is a divisional application of Chinese patent application 02818632.X "Nucleic Acid, Polypeptide, and Method for Regulating Cell Apoptosis" filed on July 23, 2002. technical field

[0002] The present invention relates to the nucleic acid and polypeptide of apoptosis-specific eukaryotic initiation factor-5A (eIF-5A) and deoxy 8-hydroxy-2,7,10-triaminodecanoic acid synthase (DHS), and the use thereof Apoptosis-specific methods of eIF-5A and DHS to regulate apoptosis. Background technique

[0003] Apoptosis is a genetically programmed cellular event characterized by well-defined morphological features such as cell shrinkage, chromatin condensation, nuclear fragmentation, and membrane blebbing. Kerr et al. (1972) Br. J. Cancer, 26, 239-257; Wyllie et al. (1980) Int. Rev. Cytol., 68, 251-306. It plays an important role in normal tissue development and homeostasis, and defects in the apoptotic program are thought to contribute to a variety of human disease...

Claims

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