Momordica grosvenori liver-protecting preparation and production method thereof

A technology of Luo Han Guo and preparations, which is applied in the field of preparing liver-protecting preparations from Chinese herbal medicines, and can solve problems such as not being prepared

Inactive Publication Date: 2008-04-30
防城港市现代科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, in the published literature we have seen, apart from making Luo Han Guo into cough syrup, there are no other preparations for the treatment of symptoms such as hyperglycemia, hyperlipidemia or liver protection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] First crush the Luo Han Guo, heat and extract with water, then separate the extract with a D101 macroporous resin column or other resins, elute with deionized water and ethanol respectively until colorless, collect the ethanol eluate, concentrate under reduced pressure to the Paste, add water to dissolve and filter, decolorize the filtrate with a D280 type macroporous resin column, concentrate under reduced pressure, and dry to obtain mogrosides with a purity of more than 80% respectively. Take 100 parts by weight of the refined product extracted from Luo Han Guo sweet glycoside), adding 100-500 parts by weight of polylactose or dextrin as a forming agent, mixing uniformly, and performing wet granulation or dry granulation to obtain Luo Han Guo liver-protecting granules.

Embodiment 2

[0070] First crush the Luo Han Guo, heat and extract with water, then separate the extract with a D101 macroporous resin column or other resins, elute with deionized water and ethanol respectively until colorless, collect the ethanol eluate, concentrate under reduced pressure to the Paste, add water to dissolve and filter, the filtrate is decolorized with a D280 type macroporous resin column, concentrated under reduced pressure, and dried to obtain mogrosides with a purity of more than 80%. sweet glycosides), add 50 kilograms of lactose or pregelatinized starch, 150 kilograms of calcium sulfate or calcium carbonate, and 20 kilograms of microcrystalline cellulose, mix, compress on tablet machine, then coat with coating powder, obtain the Luo Han Guo Bao Liver tablets.

Embodiment 3

[0072] First crush the Luo Han Guo, heat and extract with water, then separate the extract with a D101 macroporous resin column or other resins, elute with deionized water and ethanol respectively until colorless, collect the ethanol eluate, concentrate under reduced pressure to the Paste, add water to dissolve and filter, the filtrate is decolorized with a D280 type macroporous resin column, concentrated under reduced pressure, and dried to obtain mogrosides with a purity of more than 80%. sweet glycoside), adding 100-500 kg of auxiliary materials, mixing, and filling in hard capsules to obtain Luo Han Guo Liver-protecting Hard Capsules. The auxiliary materials are diluents, glidants and disintegrants, wherein the diluents are selected from starch and lactose; the glidants are selected from micropowder silica gel, talcum powder or microcrystalline cellulose; the disintegrators are selected from dry starch, microcrystalline cellulose , pregelatinized starch, cross-linked polyv...

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Abstract

The invention relates to a process for preparation of a hepatoprotective medicament which is prepared from an extract of cucurbitaceous momordica grosvenori and characterized in that momordica grosvenori is firstly disintegrated, heated and extracted through water, and the extracting liquid is separated, concentrated and dried through macroreticular resin column. Purification extracted from momordica grosvenori is prepared into granules, tablets, capsules, oral liquid, dropping pills or syrup, and the medicaments have protective effect to CCI4 chronic liver injury of rats and can decrease activity of ALT and AST in serum and increase TP and ALB, and activity of SOD and GSH-px of liver tissue, reduce MDA content of liver tissue and improve pathologic change of liver tissue.

Description

technical field [0001] The invention relates to a method for preparing a hepatoprotective preparation with Chinese herbal medicines, in particular to a method for preparing a hepatoprotective preparation with a Luo Han Guo extract. Background technique [0002] Hepatitis is a very dangerous disease. my country is a high-incidence area of ​​hepatitis. According to relevant information, there are currently about 120 million people in the country carrying hepatitis B virus (HBV), of which there are about 30 million patients with hepatitis B symptoms. The annual incidence of acute hepatitis is about 1.4 million to 2 million people, ranking third among infectious diseases. Among them, 20% of acute hepatitis B and 50% to 60% of acute hepatitis C may develop into chronic hepatitis, and the treatment period of chronic hepatitis is long. Difficult to cure and poor prognosis, a considerable number of patients with chronic hepatitis will further develop into liver cirrhosis, liver can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K9/00A61K9/08A61K9/16A61K9/20A61K9/48A61K9/52A61P1/16A61K131/00
Inventor 王勤王志萍李爱媛肖刚
Owner 防城港市现代科技有限公司
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