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Method for preparing polyalcohol stephanoporate bracket for tissue project by poragen agglutinating filtering off method

A porous scaffold and tissue engineering technology, which is applied in the field of preparation of polymer porous scaffolds for tissue engineering, and can solve the problems of low porosity, unsatisfactory performance and use effect of scaffolds, etc.

Inactive Publication Date: 2008-05-14
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its disadvantage is that the porosity of the scaffold is low, usually less than 80%.
[0009] Looking at the above-mentioned porous scaffolds obtained by the current preparation methods, there are corresponding deficiencies, and the performance and use effect are still unsatisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the method for the preparation of polylactic acid porous scaffold

[0024] (1) Adopt the domestic standard sieve to classify the sodium chloride particles, and put the sodium chloride particles with a particle size of 180 to 250 μm into the mould;

[0025] (2) Put the mold containing the sodium chloride particles into a constant temperature and humidity box, set the temperature at 37°C, and the relative humidity at 95%, take it out after 10 hours, so that the sodium chloride in the mold has a certain degree of bonding, put Dry in a vacuum oven for 2 hours;

[0026] (3) casting the polylactic acid chloroform solution that concentration is 0.1g / ml in the mould, after the chloroform volatilizes, obtain the mixture of sodium chloride and polylactic acid;

[0027] (4) Soak the above mixture in deionized water, replace the deionized water every 4 hours, and after 48 hours, the sodium chloride is all filtered out, and the product is taken out;

[0028] (5) vacu...

Embodiment 2

[0030] Example 2: Preparation of hydroxyapatite / polylactic acid composite porous scaffold

[0031] (1) Adopt domestic standard sieves to classify the sodium chloride particles, and put the sodium chloride particles with a particle size of 250 μm to 425 μm into the mould;

[0032] (2) Put the mold containing the sodium chloride particles into a constant temperature and humidity box, set the temperature at 37°C, and the relative humidity at 95%, take it out after 6 hours, so that the sodium chloride in the mold has a certain degree of bonding, put Dry in a vacuum oven for 2 hours;

[0033] (3) configure the polylactic acid chloroform solution of 0.05g / ml, put a certain amount of nano-hydroxyapatite into the solution, stir until the hydroxyapatite forms a uniform suspension in the polylactic acid chloroform solution;

[0034] (4) Cast the mixed solution into a mould, and after the chloroform volatilizes, a mixture of sodium chloride, hydroxyapatite and polylactic acid is obtaine...

Embodiment 3

[0038] Embodiment 3: Preparation of polycaprolactone porous scaffold

[0039] (1) Use a domestic standard sieve to classify the glucose particles, and put the glucose particles with a particle size of 250 μm to 425 μm into the mold;

[0040] (2) Put the mold containing glucose granules into a constant temperature and humidity box, set the temperature at 60°C, and the relative humidity at 80%, take it out after 10 hours, so that the glucose in the mold has a certain degree of bonding, and put it in a vacuum oven to dry 4 hours;

[0041] (3) The polycaprolactone chloroform solution of 0.05g / ml is cast in the mould, after the chloroform volatilizes, obtain the mixture of glucose, polycaprolactone;

[0042] (4) Soak the above mixture in deionized water, replace the deionized water every 4 hours, and take out the product after 48 hours;

[0043] (5) vacuum drying, remove moisture, obtain polycaprolactone porous scaffold;

[0044]The pore diameter of the obtained porous scaffold ...

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Abstract

The invention relates to a preparation method of porous polymer scaffolds used for tissue engineering by means of pore-forming agent bonding and filtering method, comprising two steps: firstly, a mold containing pore-forming agent is positioned in the environment with certain temperature and certain humidity, and the pore-forming agent in the mold then can bond together; secondly, polymer solution is cast into the mold, the pore-forming agent in the mold is filtered out after the solvent volatilizing, and a porous polymer scaffold can be obtained. The invention has the advantages of simple equipment, easy operation, controllable aperture, high porosity, excellent connectivity, and fitness for three-dimension porous cell scaffolds in tissue engineering and other application fields.

Description

technical field [0001] The invention relates to a preparation method of a porous polymer scaffold for tissue engineering, in particular to a method for preparing a porous polymer scaffold for tissue engineering by a porogen binding and leaching method. Background technique [0002] The repair of trauma and diseased tissue has always been one of the difficult problems in the medical field. Scholars at home and abroad have conducted a lot of related research and clinical practice for a long time. For these problems, tissue engineering technology has brought new methods to it. The specific idea is: the normal tissue cells cultured and expanded in vitro are adsorbed on a biomaterial with good biocompatibility and can be absorbed by the body to form a complex, and the cell-biomaterial complex is implanted into body tissues and organ diseases. At the damaged site, cells form new corresponding tissues and organs with shape and function during the process of biomaterials being grad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/18A61L27/26A61L27/32
Inventor 任杰陈楚谭庆刚
Owner TONGJI UNIV
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