Medicine composition for treating hepatitis B

A technology for hepatitis B and a composition is applied in the field of research and development of traditional Chinese medicine, and achieves the effects of low production cost, rapid separation and purification method, and favorable industrial production.

Inactive Publication Date: 2008-06-11
周亚伟
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report about the preparation method of berberine I and its ap

Method used

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  • Medicine composition for treating hepatitis B

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Effect test

Embodiment 1

[0172] The preparation method of embodiment 1 berberine I

[0173] Get 3000g of Coptis chinensis medicinal material (3.19% of the content of berberine I in the medicinal material), be ground into the medicated powder of crossing 10 mesh sieves. Reflux with 70% ethanol that is 12 times the weight volume (v / w) of the medicinal material, and the obtained percolation solution is concentrated at 60° C. to a concentrated solution with a relative density of 1.18 to 1.20. The resulting concentrated solution is diluted with water, centrifuged, and the obtained supernatant is The speed of 1.2L / Kg.h passes through the D-101 macroporous adsorption resin column (resin diameter: height = 1:10, the amount of resin is 2.5 times the weight of the medicinal material), after the medicinal liquid has completely flowed into the resin, use 20 times the medicinal material in sequence Water by weight volume (v / w), 32 times the weight volume of medicinal materials (v / w) 15% ethanol elutes impurities, ...

Embodiment 2

[0174] The preparation method of embodiment 2 berberine I

[0175] Get 84kg of Coptis chinensis medicinal material (3.19% of the content of berberine I in the medicinal material), be ground into the medicated powder of crossing 10 mesh sieves. Percolate with 70% ethanol at a speed of 8 times the weight volume (v / w) of the medicinal material, and the obtained percolation solution is concentrated at 60° C. to a concentrated solution with a relative density of 1.18 to 1.20. The obtained concentrated solution is diluted with water, centrifuged, and the obtained supernatant is Through the ZTC type resin column, after the medicinal liquid flows into the resin completely, use 18 times the weight volume (v / w) of the medicinal material (v / w) of water, 25 times the weight volume (v / w) of the medicinal material 15% ethanol to elute the impurities, and then use 25 times the weight volume (v / w) of the medicinal material to elute the impurities. The weight volume (v / w) of the medicinal mate...

Embodiment 3

[0176] [Embodiment 3] Preparation process of berberine I for injection

[0177] Prescription: berberine I60.0g, made into 1000 sticks.

[0178] Preparation method: Take 60.0g of Pipericillin I, add about 2800mL of water for injection, dissolve in a water bath at 65°C, add a total preparation amount of 2.0‰ activated carbon (6.0g), stir for half an hour, filter, add water to the filter to 3000mL, and then Graded filtration with 0.45 μm and 0.22 μm microporous membranes, the filtrate was quantitatively dispensed into 10 mL vials at 3 mL per bottle, freeze-dried, backfilled with high-purity nitrogen, stoppered, capped, and packaged.

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Abstract

The invention belongs to the new medicine researching and developing filed of traditional medicine, which particularly relates to a medicine combination for curing serum hepatitis, the medicine combination is constituted by picrorhizae glycosides I and findings which can be accepted in pharmacy, wherein the content of picrorhizae glycosides I is over 90%. The traditional medicine combination has a better treatment effect for serum hepatitis.

Description

[0001] The present invention is a divisional application of the invention patent application with the application number 200410098646.4. The original application date is December 15, 2004. The original application name is the application of Pibroside I in the preparation of drugs for the treatment of hepatitis B and its preparation and preparation method. . technical field [0002] The invention belongs to the field of research and development of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating hepatitis B. Background technique [0003] As we all know, China is a big country with hepatitis B disease. At present, it is estimated that there are more than 600 kinds of medicines for the treatment of viral hepatitis in the world, but there is no satisfactory treatment medicine so far. Dr. Han Sang-tae, Permanent Honorary Chairman of the Western Pacific Region of the World Health Organization, said that the most commonly used d...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/06A61K9/08A61K9/10A61K9/12A61K9/16A61K9/20A61K9/48A61K9/70A61P1/16A61P31/20
Inventor 周亚伟
Owner 周亚伟
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