Lamy stationary slice and preparing method thereof

Abstract

The invention discloses a lamivudine tablet and the related preparation method. The lamivudine tablet is made of 150 portions(based on weight) of lamivudine, 70 to 90 portions of starch, 5 to 10 portion of dry starch, 1 to 1.5 portions of magnesium stearate and 15 to 20 portions of starch slurry with a concentration of 10%. The invention has the advantages of high finished product rate and low cost.

Description

technical field

[0001] The invention relates to a lamivudine tablet and a preparation method thereof. Background technique

[0002] Lamivudine, whose chemical name is (2R-cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-1H- pyrimidin-2-one.

[0003] Its chemical structural formula is as follows:

[0004] Molecular formula: C 8 h 11 N 3 o 3 S molecular weight: 229.26

[0005] Lamivudine is a cytidine derivative (3'thiocytidine levoisomer), which is an oral 2'3'dideoxynucleotide. It can inhibit the activity of reverse transcriptase of hepatitis B virus and human immunodeficiency virus (such as human immunodeficiency virus-1 and virus-2 (HIV-1 and HIV-2)), without damaging the mitochondria of cells, and belongs to nucleoside Reverse Transcriptase Inhibitors (NRTIs).

[0006] Experimental studies and clinical trials have proved that lamivudine can rapidly reduce the concentration of hbv dna and improve liver tissue lesions.

[0007] Studies have demonstrated that...

Examples

Embodiment 1

[0030] In the present embodiment, the weight of each raw material is respectively:

[0031] Lamivudine 150g, starch 70g, dry starch 5g, magnesium stearate 1g, 10% starch slurry 15g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0032] Dosage and dosage:

[0033] Lamivudine is usually used in combination with other anti-AIDS drugs. HIV-infected patients, orally, twice a day, 150mg each time for adults (the dose of the active ingredient lamivudine); adults with a body weight of less than 50kg, twice a day, 4mg / kg each time (until the highest dose is 150mg ); the dosage of children should be increased, because the bioavailability in children is relatively low.

Embodiment 2

[0035] In the present embodiment, the weight of each raw material is respectively:

[0036] Lamivudine 150g, starch 90g, dry starch 10g, magnesium stearate 1.5g, 10% starch slurry 20g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0037] All the other are the same as embodiment one.

Embodiment 3

[0039] In the present embodiment, the weight of each raw material is respectively:

[0040] Lamivudine 150g, starch 80g, dry starch 7.5g, magnesium stearate 1.25g, 10% starch slurry 17.5g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0041] All the other are the same as embodiment one.

technical field

[0001] The invention relates to a lamivudine tablet and a preparation method thereof. Background technique

[0002] Lamivudine, whose chemical name is (2R-cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-1H- pyrimidin-2-one.

[0003] Its chemical structural formula is as follows:

[0004] Molecular formula: C 8 h 11 N 3 o 3 S molecular weight: 229.26

[0005] Lamivudine is a cytidine derivative (3'thiocytidine levoisomer), which is an oral 2'3'dideoxynucleotide. It can inhibit the activity of reverse transcriptase of hepatitis B virus and human immunodeficiency virus (such as human immunodeficiency virus-1 and virus-2 (HIV-1 and HIV-2)), without damaging the mitochondria of cells, and belongs to nucleoside Reverse Transcriptase Inhibitors (NRTIs).

[0006] Experimental studies and clinical trials have proved that lamivudine can rapidly reduce the concentration of hbv dna and improve liver tissue lesions.

[0007] Studies have demonstrated that...

Examples

Embodiment 1

[0030] In the present embodiment, the weight of each raw material is respectively:

[0031] Lamivudine 150g, starch 70g, dry starch 5g, magnesium stearate 1g, 10% starch slurry 15g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0032] Dosage and dosage:

[0033] Lamivudine is usually used in combination with other anti-AIDS drugs. HIV-infected patients, orally, twice a day, 150mg each time for adults (the dose of the active ingredient lamivudine); adults with a body weight of less than 50kg, twice a day, 4mg / kg each time (until the highest dose is 150mg ); the dosage of children should be increased, because the bioavailability in children is relatively low.

Embodiment 2

[0035] In the present embodiment, the weight of each raw material is respectively:

[0036] Lamivudine 150g, starch 90g, dry starch 10g, magnesium stearate 1.5g, 10% starch slurry 20g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0037] All the other are the same as embodiment one.

Embodiment 3

[0039] In the present embodiment, the weight of each raw material is respectively:

[0040] Lamivudine 150g, starch 80g, dry starch 7.5g, magnesium stearate 1.25g, 10% starch slurry 17.5g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0041] All the other are the same as embodiment one.