Lamy stationary slice and preparing method thereof

A technology of lamivudine tablets and lamivudine, which is applied in the direction of pill delivery and antiviral agents, can solve the problems of high cost, low yield and high cost, and achieve low cost, high yield and high technology simple effect

Inactive Publication Date: 2008-06-18
ZHUHAI HUAAO IMPORT & EXPORT CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, when the raw material is selected and prepared, the yield is low, and the corresponding cost remains high, so the currently commercially available medicines related to lamivudine are all very expensive.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In the present embodiment, the weight of each raw material is respectively:

[0031] Lamivudine 150g, starch 70g, dry starch 5g, magnesium stearate 1g, 10% starch slurry 15g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0032] Dosage and dosage:

[0033] Lamivudine is usually used in combination with other anti-AIDS drugs. HIV-infected patients, orally, twice a day, 150mg each time for adults (the dose of the active ingredient lamivudine); adults with a body weight of less than 50kg, twice a day, 4mg / kg each time (until the highest dose is 150mg ); the dosage of children should be increased, because the bioavailability in children is relatively low.

Embodiment 2

[0035] In the present embodiment, the weight of each raw material is respectively:

[0036] Lamivudine 150g, starch 90g, dry starch 10g, magnesium stearate 1.5g, 10% starch slurry 20g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0037] All the other are the same as embodiment one.

Embodiment 3

[0039] In the present embodiment, the weight of each raw material is respectively:

[0040] Lamivudine 150g, starch 80g, dry starch 7.5g, magnesium stearate 1.25g, 10% starch slurry 17.5g. 1000 lamivudine tablets can be prepared, each containing 150 mg of active ingredient lamivudine.

[0041] All the other are the same as embodiment one.

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PUM

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Abstract

The invention discloses a lamivudine tablet and the related preparation method. The lamivudine tablet is made of 150 portions(based on weight) of lamivudine, 70 to 90 portions of starch, 5 to 10 portion of dry starch, 1 to 1.5 portions of magnesium stearate and 15 to 20 portions of starch slurry with a concentration of 10%. The invention has the advantages of high finished product rate and low cost.

Description

technical field [0001] The invention relates to a lamivudine tablet and a preparation method thereof. Background technique [0002] Lamivudine, whose chemical name is (2R-cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-1H- pyrimidin-2-one. [0003] Its chemical structural formula is as follows: [0004] Molecular formula: C 8 h 11 N 3 o 3 S molecular weight: 229.26 [0005] Lamivudine is a cytidine derivative (3'thiocytidine levoisomer), which is an oral 2'3'dideoxynucleotide. It can inhibit the activity of reverse transcriptase of hepatitis B virus and human immunodeficiency virus (such as human immunodeficiency virus-1 and virus-2 (HIV-1 and HIV-2)), without damaging the mitochondria of cells, and belongs to nucleoside Reverse Transcriptase Inhibitors (NRTIs). [0006] Experimental studies and clinical trials have proved that lamivudine can rapidly reduce the concentration of hbv dna and improve liver tissue lesions. [0007] Studies have demonstrated that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/513A61P31/12
Inventor 于寅辰
Owner ZHUHAI HUAAO IMPORT & EXPORT CORP
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