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Recombinant flavivirus vaccines

A technology of flavivirus and yellow fever virus, applied in the field of vaccines containing recombinant flavivirus, can solve the problem of not being approved

Inactive Publication Date: 2008-06-18
ACAMBIS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] Many medically important flaviviruses with viscerotropic properties do not currently have approved vaccines, such as West Nile virus, dengue virus, and Omsk hemorrhagic fever virus

Method used

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  • Recombinant flavivirus vaccines
  • Recombinant flavivirus vaccines
  • Recombinant flavivirus vaccines

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Embodiment Construction

[0030] The present invention provides recombinant flaviviruses useful in therapeutic methods such as vaccination methods. The focus of the flavivirus of the present invention lies in the presence of attenuating mutations in the viral genome. These mutations can attenuate the virus by, for example, reducing the viscerotropic and / or neurotropic tropism of the virus. Such mutations may be present in regions within the flavivirus genome including the 3' untranslated region (3'UTR), capsid sequence and / or envelope sequence. As discussed further below, the mutations of the invention can be used to fine-tune the attenuation of vaccine strains that already contain one or more other attenuating mutations. Thus, for example, mutations of the invention can be identified by resulting in reduced plaque size in plaque assays and / or reduced viremia in animal models (see below). Thus, the mutations of the present invention provide a higher level of safety with regard to attenuation of such ...

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Abstract

The present invention provides recombinant flavivirus vaccines that can be used to prevent and treat flavivirus infections. The vaccine of the invention contains a recombinant flavivirus containing attenuating mutations.

Description

Background of the invention [0001] The present invention relates to vaccines comprising recombinant flaviviruses. [0002] Flaviviruses are small enveloped positive-sense RNA viruses that are usually transmitted by infected mosquitoes and ticks. Some flaviviruses, such as yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are an ongoing or potential threat to public health worldwide. Yellow fever virus, for example, has been the cause of epidemics in some jungle areas of sub-Saharan Africa and parts of South America. Although many yellow fever virus infections are mild, the disease can also cause severe, life-threatening illness. The initial or acute phase of the illness is usually characterized by high fever, chills, headache, back pain, muscle pain, decreased appetite, nausea, and vomiting. After 3 to 4 days, these symptoms disappear. In some patients, symptoms then reappear as the disease enters its so-call...

Claims

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Application Information

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IPC IPC(8): A61K39/29C12P21/06C07H21/02
CPCY02A50/30
Inventor 康斯坦丁·V·帕格切夫法沙德·吉拉克胡托马斯·P·莫纳思
Owner ACAMBIS INC
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