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External nanometer titanium dioxide antiinflammatory agent

A technology of nano-titanium dioxide and ointment, which is applied in the direction of anti-inflammatory agents, ointment delivery, medical preparations containing active ingredients, etc., and can solve problems such as side effects

Inactive Publication Date: 2008-06-25
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The conventional anti-inflammatory drugs mentioned above all have side effects of varying degrees

Method used

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  • External nanometer titanium dioxide antiinflammatory agent
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Examples

Experimental program
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Effect test

Embodiment 1

[0032] 16.4wt% nano-TiO 2 (Nano-titanium dioxide (P25), produced by degussa company in Germany, is hydrophilic, prepared by gas phase method, TiO 2 Content ≥99.5%; its specific surface area is 50±15m 2 / g, average primary particle size is 21nm; PH value (in 4% dispersion) 3.5-4.5; water content (2 hours at 105°C) ≤ 1.5), 55.7wt% white petrolatum, 27.9wt% lanolin Uniform, the preparation cost the invention of nano titanium dioxide (TiO 2 ) Anti-inflammatory ointment for external use 1.

Embodiment 2

[0034] 16.4wt% nano-TiO 2 , 83.1wt% fat-soluble matrix (55.4wt% white petrolatum, 27.7wt% lanolin), 0.5wt% erythromycin, mixed uniformly, and formulated into the nano titanium dioxide (TiO 2 ) Anti-inflammatory ointment for external use 2.

Embodiment 3

[0036] 16.4wt% nano-TiO 2 , 82.6wt% fat-soluble matrix (55.1wt% white petrolatum, 27.5wt% lanolin), 1.0wt% erythromycin, mixed uniformly, and formulated into the nano titanium dioxide (TiO 2 ) Anti-inflammatory ointment for external use 3.

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Abstract

The invention relates to a nanometer titanium dioxide external anti-inflammatory ointment, which comprises effective dose of nanometer titanium dioxide. The nanometer titanium dioxide external anti-inflammatory ointment provided by the invention is preferred with 0.1-16.4 percent nanometer titanium dioxide, 82.6- 99.9 percent fat-soluble matrix, oil-in-water emulsion matrix, paints, water-solubility ointment matrix and 0-1.0 percent erythrocin or chloromycetin. The ointment overcomes the toxic and side effects of the existing anti-inflammatory drugs, such as the gastrointestinal reaction, anaphylactic reaction, response of central nervous system and inhibiting the marrow regeneration, etc. The invention is an external anti-inflammatory ointment with good curative effects, little or without toxic or side effects.

Description

Technical field [0001] The invention relates to a nano titanium dioxide (TiO 2 ) Anti-inflammatory ointment for external use. Background technique [0002] Inflammation is a complex process of defense-based damage caused by the body to various inflammatory stimuli. It is an extremely common and important energy-saving pathological process. The currently used anti-inflammatory drugs mainly involve two categories: non-hormonal and hormonal. Non-hormonal anti-inflammatory drugs are further subdivided into: salicylic acid, aniline, pyrazolone, and organic acid. [0003] The common mechanism of action of non-hormones is to inhibit cyclooxygenase (COX) and interfere with the biosynthesis of prostaglandin (PG) in the body. COX has two isoenzymes, COX-1 and COX-2. COX-1 is a structural type, mainly found in blood vessels, stomach, kidney and other tissues. It participates in the regulation of vasomotor, platelet aggregation, gastric mucosal blood flow, gastric mucus secretion and renal f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K9/06A61K47/44A61P29/00A61K31/7048A61K31/165A61K47/06
Inventor 王月丹郑玉峰初明李然中黄鹤韩巍徐兰朱蕴兰张秀春邓璐瑶贺琼吴栗洋
Owner PEKING UNIV
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