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Method for refining polyglucose

A refining method and glucose technology, which are applied in the field of blood volume expansion medicine, can solve the problems of dangerous production environment, residual alcohol substances, and high production safety level, so as to reduce production cost, reduce sugars with low degree of condensation, and improve distribution uniformity. Effect

Inactive Publication Date: 2008-07-02
CHONGQING DAXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the process of preparing condensed glucose is to obtain the semi-finished product of condensed glucose after solid-state condensation reaction of anhydrous glucose, acid and catalyst at high temperature for a certain period of time, and then use a large amount of alcohol to wash to obtain the finished product, resulting in the residue of alcohol in the product. Dangerous environment, high production safety level

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] Weigh the semi-finished condensed glucose to make a solution containing 40 grams of condensed glucose semi-finished product per 200ml, the solvent is hot water at 50°C, add 0.5g of activated carbon to each 100ml solution, and heat up to 100-120°C under stirring at 250-300r / min , adjust the pH to 4-8, keep stirring for 50-60 minutes.

[0023] Pass through a plate and frame filter for coarse filtration, and then use a folded filter core filter for fine filtration, and then pass the hollow fiber ultrafiltration when the temperature of the filtrate is controlled at 30-50°C and the concentration is controlled at 1-30% g / mL (w / v). The molecular weight of the membrane is divided, and the molecular weight cut-off of the molecular weight membrane element is 2000 and 16000, the operating pressure is 0.20-0.34MPa, and the water permeability of the membrane is 1000-1100L / h.

[0024] The filtrate is vacuum-concentrated into a liquid of 30-40% g / mL under the conditions of a vacuum de...

example 2

[0026] Weigh the semi-finished condensed glucose to make a solution containing 60 grams of the condensed glucose semi-finished product per 200ml, the solvent is hot water at 50°C, add 0.3g of diatomaceous earth to each 100ml solution, and heat up to 80~80℃ under stirring at 90~150r / min 100°C, adjust the pH to 4-8, keep stirring for 40-50min.

[0027] Pass through a plate and frame filter for coarse filtration, and then use a folded filter core filter for fine filtration, and then pass the hollow fiber ultrafiltration when the temperature of the filtrate is controlled at 20-30°C and the concentration is controlled at 1-30% g / mL (w / v). The molecular weight of the membrane is divided, and the molecular weight cut-off of the molecular weight membrane element is 2000 and 16000, the operating pressure is 0.20-0.30MPa, and the water permeability of the membrane is 1000-900L / h.

[0028] The filtrate is vacuum-concentrated into a liquid of 50-60% g / mL under the conditions of a vacuum d...

example 3

[0030] Weigh the semi-finished condensed glucose to make a solution containing 30 grams of condensed glucose semi-finished product per 200ml, the solvent is hot water at 50°C, add 0.2g of activated carbon to each 100ml solution, and heat up to 70-80°C under stirring at 60-90r / min , adjust the pH to 4-8, keep stirring for 30-40 minutes.

[0031] Pass through a plate and frame filter for coarse filtration, and then use a folded filter core filter for fine filtration, and then pass the hollow fiber ultrafiltration when the temperature of the filtrate is controlled at 10-20°C and the concentration is controlled at 1-30% g / mL (w / v). The molecular weight of the membrane is divided, and the molecular weight cut-off of the molecular weight membrane element is 2000 and 16000, and its operating pressure is 0.10-0.15MPa; the water permeability of the membrane is 800-900L / h.

[0032] The filtrate is vacuum-concentrated into a 20-30% g / mL liquid under the conditions of a vacuum degree of 0...

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Abstract

The invention provides a refine preparation method of polyglucose. Glucose is solid-phase condensed by catalyst in the conditions of high temperature and acid to obtain polyglucose semiproduct to prepare aqueous solution of the polyglucose semiproduct and then the aqueous solution is added with sorbent, heated and stirred; rough filtration and straining are carried out and hollow fiber ultrafiltration membrane is used for measuring off molecular weight; the filtrate is condensed to obtain polyglucose solid powder by spray drying. The polyglucose product obtained by the method of the invention is uniform and steady in quality, safe and environment protective in production.

Description

technical field [0001] The present invention relates to a blood volume expansion drug, in particular to a refining method for condensing glucose. Background technique [0002] Condensed glucose is a certain colloid osmotic pressure blood volume expansion drug. This product has the effect of increasing plasma osmotic pressure and increasing blood volume. Early diuretic properties. Condensed glucose can maintain blood volume in blood vessels; excretion is slow, but it does not accumulate in the body for a long time. The long-term clinical application of this product has proved that it has no antigenicity, no toxicity, and can improve microcirculation. It is an excellent substitute plasma for the resuscitation of fatal blood loss patients. [0003] At present, the process of preparing condensed glucose is to obtain the semi-finished product of condensed glucose after solid-state condensation reaction of anhydrous glucose, acid and catalyst at high temperature for a certain pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02B01D69/08A61K31/715
Inventor 郭明岳光陈珊冉启平任钦合
Owner CHONGQING DAXIN PHARMA
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