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Polypeptide medicament for treating tumor caused by human papillomavirus type 18 or vaccine

A technology for human papillomavirus and tumors, applied in the field of biomedicine, can solve the problems of anaphylactic shock, large cell damage, leukopenia, etc., and achieve the effect of facilitating automatic mass production, convenient transportation and storage, and no toxic and side effects

Inactive Publication Date: 2008-07-09
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this method is: although it can kill the cells infected by HPV virus, the radiation damages the normal tissue cells more
The main disadvantage of this method is: although it can kill cells infected by HPV virus, the chemotherapy drugs are more toxic to normal tissue cells, and side effects such as anaphylactic shock, vomiting, leukopenia, and decreased resistance occur.

Method used

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  • Polypeptide medicament for treating tumor caused by human papillomavirus type 18 or vaccine
  • Polypeptide medicament for treating tumor caused by human papillomavirus type 18 or vaccine
  • Polypeptide medicament for treating tumor caused by human papillomavirus type 18 or vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: its amino acid sequence can be:

[0026]

[0027] The polypeptide can stimulate HLA-A*0201 positive human peripheral blood mononuclear cells in vitro, increase the number of these peripheral blood mononuclear cells transformed into cytotoxic T lymphocytes (CTL for short) by 60%, and activate CTL to dissolve For HPV18 tumor cells, the lysis rate is 80%.

Embodiment 2

[0028] Embodiment 2: its amino acid sequence can also be:

[0029]

[0030] The polypeptide can stimulate peripheral blood mononuclear cells of HLA-A*0201 positive human body in vitro, increase the number of these peripheral blood mononuclear cells transformed into cytotoxic T lymphocytes (CTL for short) by 50%, and activate CTL to dissolve For HPV18 tumor cells, the lysis rate is 71.29%.

Embodiment 3

[0031] Embodiment 3: its amino acid sequence can also be:

[0032]

[0033] The polypeptide can stimulate HLA-A*0201 positive human peripheral blood mononuclear cells in vitro, increase the number of these peripheral blood mononuclear cells transformed into cytotoxic T lymphocytes (CTL for short) by 55%, and activate CTL to dissolve For HPV18 tumor cells, the lysis rate is 60%

[0034] The amino acid sequence method described above is an existing mature technology, which is made according to the following method:

[0035]Adopt the standard Fmoc scheme, initially select 0.0125mmol, PSC resin (produced by ABI company, batch number A5F013), respectively according to the sequence characteristics described in claim 1, 2, 3 or 4, make the peptide chain extend from the C terminal to the N terminal one by one , the consumption of each amino acid raw material (produced by American ABI Company) is 0.1 mmol. Various amino acid protection groups are: the alpha amino group of each ami...

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PUM

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Abstract

A polypeptide drug or bacterin for curing tumor caused by Human Papillomavirus Type 18 is characterized in that the aminophenol order is amido end- VAWDSVYYM- carboxyl end, which is a multi-copy serial structure with lysine as a joint and a plurality of aminophenol orders connected. The present invention has the advantages of convenient transport and storage as well as automatic mass production. The present invention also has the capacity of activating specific cytotoxic T lymphocytes (CTL) and the specific CTL cell can kill, damage and dissolve target cells with the relative tumor sign Human Papillomavirus Type 18. The present invention has obvious effect and no side effect.

Description

(1) Technical field [0001] The invention relates to the field of biomedicine, in particular to a polypeptide drug or vaccine for tumors induced by human papillomavirus type 18. (two), background technology [0002] The full English name of human papilloma virus is human papilloma virus, HPV for short. [0003] Cervical cancer is the most common gynecological malignancy. Globally, cervical cancer is the second leading cause of female cancer death, with about 500,000 new cases every year, 20% of which occur in China. The age of occurrence is bimodal, 35-39 years old and 60-64 years old. In recent years, it has become clear that almost all cervical cancers are caused by human papillomavirus. Of these, more than two-thirds of cervical cancer cases can be attributed to two types of HPV: types 16 and 18. [0004] The etiology of cervical cancer has not yet been fully understood, and it may be related to sexual disorder, premature sexual life, early childbirth, prolificacy, geog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K38/16A61K38/08A61K39/12A61P35/00
Inventor 吕凤林李元朝
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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