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Chitosan hydrogel and preparation method thereof

A technology of chitosan and gel, which is applied in the field of chitosan hydrogel and its preparation, can solve the problems of poor stability, uncontrollable gel temperature, and no temperature reversibility of chemical gel, and achieves a simple and convenient preparation method Effect

Inactive Publication Date: 2008-07-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the formation of these chitosan hydrogels all need to add a cross-linking agent in addition, and the chemical gels formed do not have temperature reversibility. Although the physical gels formed have reversibility, some have poor stability and some have poor stability. The gel temperature cannot be adjusted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Chitosan with a molecular weight of 600,000 and a degree of deacetylation of 50% is added to an aqueous solution of acetic acid with a volume concentration of 30%, stirred to form a stable solution, and then methanol and acetic anhydride are added to the solution, chitosan: acetic acid: methanol: acetic anhydride The weight ratio is 1:35:85:0.3, mix evenly, fully stir, let stand for 12 hours, then add the ethanol solution of alkali with a molar concentration of 0.5mol / L to form a gel; filter the gel, wash and dry , to obtain pretreated chitosan; then the chitosan obtained by pretreatment is stirred and dispersed in 0.5% sodium hydroxide aqueous solution, 8% potassium hydroxide aqueous solution and 0.5% urea mass concentration In the mixed solution of aqueous solution, the volume ratio of sodium hydroxide aqueous solution, potassium hydroxide aqueous solution and urea aqueous solution is 1:1:0.2. After chitosan is fully swollen, it is treated at -10°C for 12 hours to obta...

Embodiment 2

[0020] Molecular weight 200,000, the chitosan of degree of deacetylation 70% joins in the acetic acid aqueous solution that volume concentration is 20% to form stable solution, then adds methyl alcohol and acetic anhydride in solution, chitosan: acetic acid: methyl alcohol: the weight of acetic anhydride The ratio is 1: 10: 30: 1.2, mix evenly, stir fully, let stand for 6 hours, the solution is precipitated with ethanol solution of alkali with a molar concentration of 1.5mol / L, the gel is filtered, washed and dried to obtain pretreated Chitosan; the chitosan obtained by pretreatment is dispersed in the mixed solution of 4% sodium hydroxide aqueous solution, 10% potassium hydroxide aqueous solution and 3.5% urea aqueous solution with mass concentration, hydrogen The volume ratio of sodium oxide aqueous solution, potassium hydroxide aqueous solution and urea aqueous solution is 1:1:0.2. After chitosan is fully swollen, it is treated at 0°C for 24 hours to obtain a reversible temp...

Embodiment 3

[0022] Molecular weight 800,000, the chitosan of degree of deacetylation 80% joins in the acetic acid aqueous solution that volume concentration is 2% to form stable solution, then adds methyl alcohol and acetic anhydride in solution, chitosan: acetic acid: methyl alcohol: the weight of acetic anhydride The ratio is 1:90:5:1.5, mix evenly, stir fully, let stand for 9 hours, the solution is precipitated with ethanol solution of alkali with a molar concentration of 0.3mol / L, the gel is filtered, washed and dried to obtain pretreated Chitosan; the chitosan obtained by pretreatment is dispersed in the mixed solution that the mass concentration is 8% sodium hydroxide aqueous solution, the mass concentration is 2% potassium hydroxide aqueous solution and the mass concentration is 6% urea aqueous solution, hydrogen The volume ratio of sodium oxide aqueous solution, potassium hydroxide aqueous solution and urea aqueous solution is 1:1:0.2. After chitosan is fully swollen, it is treated...

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PUM

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Abstract

The invention relates to a chitosan aquagel, whose components and the content of percentage by weight are that chitosan 1-5%, potassium hydrate 1-10%, sodium-hydroxide 0.5-8%, urea 0.5-6%, and others are water. The invention adopts preprocessed chitosan with a certain acylation degree to directly mix with queous alkali, any cross linker is not added, chitosan physical aquagel can be got through low-temperature processing, and the process for preparation is simple and convenient. The temperature of gel point can be controlled in 20 DEG C to 30 DEG C through the selection of processing time, raw material ratio and the like, and the gelatin has reversible temperature responsive properties, which is expected to be used as temperature sensing material and the like.

Description

technical field [0001] The invention relates to a chitosan hydrogel and a preparation method thereof. Background technique [0002] Chitosan is the only positive linear polysaccharide in nature. Its basic unit is glucosamine. It has the characteristics of good biocompatibility, no toxicity and side effects, and rich sources. It has been used in the synthesis of food industry, pharmaceutical preparations, and medical polymer materials. and other fields have been widely developed and applied. Based on different mechanisms (covalent, ionic, hydrogen bonding), chitosan can form hydrogels, which have been reported by many. Chitosan can form chemical gels with glutaraldehyde, etc., and can also form physical gels with mercaptoacetic acid, acrylic acid, oxalic acid, etc. In addition, chitosan and metal ions or other biopolymers (for example: reduced gum, carrageenan, etc.) form ionic crosslinks through electrostatic interaction to form a gel. However, the formation of these chit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08K3/22C08K5/21C08J3/075
Inventor 胡巧玲樊敏沈家骢
Owner ZHEJIANG UNIV