Novel technique for producing 2,6-dichloro diphenylamine

A technology of dichlorodiphenylamine and a new process, applied in rearrangement reaction preparation, organic chemistry, etc., can solve the problems of large amount of wastewater, environmental impact, no wastewater treatment, etc., achieve clean production process, lower total cost, and simple method effective effect

Active Publication Date: 2008-07-30
HENAN DONGTAI PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, domestic production enterprises do not effectively treat wastewater, and mainly use dilution to discharge it, so that the amount of wastewater is larger and has a very bad impact on the environment

Method used

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  • Novel technique for producing 2,6-dichloro diphenylamine
  • Novel technique for producing 2,6-dichloro diphenylamine
  • Novel technique for producing 2,6-dichloro diphenylamine

Examples

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Embodiment 1

[0033] Chloroacetylation step: Add 30ml of industrial toluene (leave 10ml of aniline measuring cylinder for washing) and 10g of industrial aniline (10g÷93=0.1075M) into a 250ml three-necked flask equipped with a stirring reflux condenser and a thermometer, stir, and add with a dropper 12.8g (9ml) chloroacetyl chloride (12.8÷1.42=9ml, 12.8÷113=0.113M), when adding about 1ml of the first part, there will be white smoke, and the temperature will rise at the same time, block the mouth of the thermometer with a thermometer, when the white smoke After dissipating, add about 1-2ml of the second part, depending on the reading of the thermometer, do not exceed 60°C, and operate in this way until the addition is completed. When about half of the amount is added, because the temperature rise stops, it can be added directly. The process of adding chloroacetyl chloride, time No limit, as long as the temperature is less than 60°C and there is no white mist, gradually increase the temperature...

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Abstract

The invention relates to a new process for producing 2, 6-dichloro diphenylamine, which includes a chloroacetylization step, an etherification step, rearrangement and post-processing steps; wherein, the reaction formula of the final product, 2, 6-dichloro diphenylamine, is shown as the right: The process of the invention causes no effluent, and the biproducts such as the sodium glycollate, the sodium chloride, etc during the reaction are recycled and transferred into reused resources. Moreover, the production technology is clean and environmentally friendly with no wastes and reduced total cost, and no catalyst and sodium carbonate are needed.

Description

technical field [0001] The invention relates to a process for producing 2,6-dichlorodiphenylamine, in particular to a new process for producing 2,6-dichlorodiphenylamine without generating waste water. Background technique [0002] Diclofenac sodium is one of the better series of analgesic, antipyretic and anti-inflammatory chemical synthetic drugs. In addition to this variety, this series of varieties also includes potassium salt, diethylamine salt, aceclofenac and other series of varieties. There are also many types of preparations and compound varieties of this kind of medicine, and their application is constantly increasing, and they are also expanded to animal use. Therefore, the demand for 2.6-dichlorodiphenylamine is increasing year by year. At present, the annual demand in the world reaches thousands of tons. [0003] At present, the processing method of producing 2.6-dichlorodiphenylamine in the prior art is: [0004] Chloroacetylation step: Add 50ml of industria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C211/56C07C209/54
Inventor 赵径全
Owner HENAN DONGTAI PHARM
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