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Kudzuvine flower isoflavonoid extraction, its extracting method, medicinal composition and its use in pharmaceutical

An extraction method and extract technology, applied in the field of plant active ingredient extract, can solve problems such as poor water solubility of puerarin, and achieve the effects of convenient industrial production, less pollution and high efficiency

Inactive Publication Date: 2008-08-13
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, puerarin has the disadvantage of poor water solubility.

Method used

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  • Kudzuvine flower isoflavonoid extraction, its extracting method, medicinal composition and its use in pharmaceutical
  • Kudzuvine flower isoflavonoid extraction, its extracting method, medicinal composition and its use in pharmaceutical
  • Kudzuvine flower isoflavonoid extraction, its extracting method, medicinal composition and its use in pharmaceutical

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0035] [Preparation Example 1]: The method for extracting isoflavones with isoflavone content greater than 10%, 50% kudzu flower isoflavones

[0036]Take 5 kg of dried kudzu flower, add 40 kg of acetone, boil and extract for 1.5 hours, filter, and use the filtrate for later use; add 30 kg of acetone to the dregs, boil and extract for 1 hour, filter, combine the two filtrates, concentrate the combined filtrate and spray dry to obtain Pueraria japonica isoflavone extract (brown solid) with isoflavone content greater than 10%.

[0037] Add ethanol to the above extract to form an extract with a relative density of 1.1-1.3, mix the extract with alumina (200 mesh), granulate with a 20-mesh sieve, extract: alumina (1:8), and Soxhlet extractor, extraction with ethyl acetate, concentration of the extract under reduced pressure to obtain the kudzu flower extract containing more than 50% isoflavones, namely the kudzu flower isoflavone extract (brown yellow solid) with an isoflavone conte...

preparation Embodiment 2

[0038] [Preparation Example 2]: The method for extracting isoflavones with isoflavone content greater than 70%

[0039] Take 5kg of dried kudzu flower, add 40kg of water, boil and extract for 1.5 hours, filter, and the filtrate is set aside, add 30kg of water to the dregs, boil and extract for 1 hour, filter, combine the two filtrates, and concentrate the combined filtrate in vacuum to make a relative density For the thick extract of 1.1-1.3, mix the thick extract with alumina, extract: alumina (1:5), use a Soxhlet extractor, extract with acetone, cool the extract to precipitate solids, collect the solids by filtration, and add a small amount of ethanol Wash to obtain the kudzu flower extract containing more than 70% of isoflavones, that is, to obtain the kudzu flower isoflavone extract (light brown solid) with an isoflavone content of 70%.

preparation Embodiment 3

[0040] [Preparation Example 3]: the extraction method of isoflavones with isoflavone content greater than 80%

[0041] Take 5kg of dried kudzu flower, add 30kg of water, boil and extract for 2 hours, filter, and the filtrate is set aside, add 30kg of water to the dregs, boil and extract for 1 hour, filter, combine the two filtrates, and concentrate the combined filtrate to a relative density of 1.1-1.3 The thick extract, this thick extract aluminum oxide mixing material, extract: aluminum oxide (1: 10) upper Soxhlet extractor, ethyl acetate extracts, and extract concentrates, obtains the kudzu flower that contains isoflavones and is greater than 50% The extract is the kudzu flower isoflavone extract whose isoflavone content is 50%. (brown yellow solid)

[0042] The extract was recrystallized by 12 times of ethanol to obtain the kudzu flower isoflavone extract (yellow light yellow solid) with an isoflavone content greater than 80%.

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Abstract

The invention relates to a gehua isoflavone extract from flower of kudzuvine, the method of the extraction and a drug composition wherein the extract serves as an active component, characterized in that comparing to the present technology, the invention has a high process efficiency with little pollution, suited to the industrial production. Gehua glycoside in the extract is much more soluble than that as a single element, so as to obtain a better bioavailability.

Description

technical field [0001] The invention relates to an extract of effective plant components, in particular to an extract of kudzu flower isoflavones, its extraction method and its pharmaceutical composition. Background technique [0002] Flos Puerariae, also known as Pueraria Lobata (Willd.) Ohwi, is the dried flower bud of Pueraria Lobata (Willd.) Ohwi, a plant of the family Leguminosae. Cool in nature, sweet in taste, enters Gui Yang Ming Jing. "Shen Nong's Materia Medica", "Compendium of Materia Medica", etc. record that it has the effect of relieving alcohol and refreshing the spleen. Pueraria japonica is widely distributed in my country and has abundant plant resources, among which flavonoids, saponins and other active ingredients have strong pharmacological activity. However, domestic research on its chemical composition, pharmacological effects and clinical application is not deep enough. At present, Gehua Jiexing Decoction is mainly used in clinical practice in my cou...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K31/352A61P9/10A61P19/10
Inventor 仲英左春旭解砚英王菊李杰刘鲁梁玉记孙敬勇牟艳玲王元书
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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