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Soft capsule for treating rhinitis

A technology of soft capsules and rhinitis, applied in the field of medicine, can solve problems such as difficult drying, loss of active ingredients, and poor quality stability of preparations, and achieve the effects of facilitating quality control, simplifying production processes, and improving stability

Inactive Publication Date: 2008-08-13
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicine is a hard capsule preparation, and the ethanol extract of cocklebur fruit in the prescription is an oily substance. It needs to be dried to prepare a hard capsule, but the drying is difficult and easily causes a large amount of loss of active ingredients. In addition, the preparation method of the preparation The preparation process of patchouli oil in the microcapsules is complicated, and the quality is difficult to assess, resulting in poor quality stability of the preparation and affecting the clinical efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Weigh Fructus Xanthii, extract three times with ethanol under reflux, add 6 times of ethanol each time, extract for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time, filter, combine the filtrate, and reclaim ethanol from the filtrate , to obtain alcohol extract of cocklebur seed; take pig gallbladder, peel and extract juice, filter, heat and extract the resulting dry paste with ethanol, filter, take the filtrate to recover ethanol, and dry to obtain refined pig gallbladder dry paste; patchouli oil is marketed Buy.

[0028] (2) Take 152g of cocklebur seed extract, 53.4ml of patchouli oil, 130g of refined pig gallbladder paste, add 450g of pharmaceutical grade soybean oil, and 200g of beeswax to prepare a suspension and prepare it for later use. The composition of gelatin, glycerin and water in a weight ratio of 1:0.6:1.2 is made into a capsule material by a melting method, and 1000 soft capsules are prepared with the prepared suspe...

Embodiment 2

[0030] (1) Weigh Fructus Xanthii, extract three times with ethanol under reflux, add 6 times of ethanol each time, extract for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time, filter, combine the filtrate, and reclaim ethanol from the filtrate , to obtain alcohol extract of cocklebur seed; take pig gallbladder, peel and extract juice, filter, heat and extract the resulting dry paste with ethanol, filter, take the filtrate to recover ethanol, and dry to obtain refined pig gallbladder dry paste; patchouli oil is marketed Buy.

[0031] (2) Take 152g of cocklebur seed extract, 53.4ml of patchouli oil, 130g of refined pig gallbladder paste, add 350g of pharmaceutical grade soybean oil, and 300g of beeswax to prepare a suspension and prepare it for later use. Gelatin, glycerin and water in a weight ratio of 1:0.6:1.2 are made into a capsule material by a melting method, and 1000 soft capsules are prepared with the prepared suspension by a droppin...

Embodiment 3

[0033] (1) Weigh Fructus Xanthii, extract three times with ethanol under reflux, add 6 times of ethanol each time, extract for 2 hours for the first time, 1 hour for the second time and 1 hour for the third time, filter, combine the filtrate, and reclaim ethanol from the filtrate , to obtain alcohol extract of cocklebur seed; take pig gallbladder, peel and extract juice, filter, heat and extract the resulting dry paste with ethanol, filter, take the filtrate to recover ethanol, and dry to obtain refined pig gallbladder dry paste; patchouli oil is marketed Buy.

[0034] (2) Take 152g of cocklebur seed extract, 53.4ml of patchouli oil, 130g of refined pig gallbladder extract, add 450g of pharmaceutical grade soybean oil, and 100g of beeswax to prepare a suspension and prepare it for later use. The composition of gelatin, glycerin and water in a weight ratio of 1:0.6:1.2 is made into a capsule material by a melting method, and 1000 soft capsules are prepared with the prepared sus...

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PUM

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Abstract

The invention discloses a soft capsule for curing rhinitis. The soft capsule comprises a liquid medicine and a pouch material which can warp up the liquid medicine. The liquid medicine comprises components as the following weight ratio: cocklebur-alcohol extract 15 to 17 percents, patchouli 5 to 6 percents, refined gallbladder of pig dry paste 13 to 15 percents, vegetable oil 30 to 50 percents and suspending agent 10 to 30 percents; the pouch material comprises components as the following weight ratio: 1:0.4 to 0.6:0.8 to 1.2 of gelatine glue, plasticizer and water; the suspending agent comprises one or more in beeswax, hydrogenation palm oil, spermaceti oil and lecithin; the vegetable oil is a soybean oil, a peanut oil, a benne oil or a corn oil of medicine level; the plasticizer is one or two in glycerol and sorbitol. The huo gallbladder rhinitis hard capsule which is recorded by 'Chinese medicine standards' is improved to be the soft capsule shape by the invention, which is good for keeping the active ingredient, simplifies the manufacturing technique, and is propitious to quality control and improves the quality of products.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation of compound traditional Chinese medicine. Background technique [0002] Rhinitis is an acute inflammatory disease of the nasal mucosa caused by viral infection. Since the nasal cavity communicates with the oral cavity, middle ear, throat and bronchi, after rhinitis occurs, if the treatment is not thorough, it is easy to develop various inflammations and seriously affect the People's normal life, work and study, it is estimated that 10% to 25% of the world's population suffers from rhinitis, and my country has 130 to 300 million population to suffer from this disease. [0003] Huodan Biyan Capsule is a common medicine for treating rhinitis. It has the effect of clearing wind and heat and dredging nasal orifices. It is used to treat chronic rhinitis, chronic sinusitis and allergic rhinitis. Standard number: WS3-B-2822-97), its prescription is cocklebur seed extract 76g, patcho...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/48A61K47/44A61P11/02A61K35/413
Inventor 刘强吕志平
Owner SOUTHERN MEDICAL UNIVERSITY
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