Method for preparing decoquinate premix

A technology for the preparation of dichnidine, which is applied in the field of preparation of poultry medicine, can solve the problems of large environmental pollution, high cost of finished products, and high cost, and achieve the effect of low overall cost and mild reaction conditions

Inactive Publication Date: 2008-08-13
凌青云
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Problems solved by technology

[0021] In method 1., since 3,4-dihydroxynitrobenzene is not produced domestically, the import cost is very high, and ring closure is to use diphenyl ether as a solvent at 250° C., which has large environmental pollution and lower yield (only 50% )Defects
[0022...

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  • Method for preparing decoquinate premix
  • Method for preparing decoquinate premix
  • Method for preparing decoquinate premix

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specific Embodiment approach

[0036] The first step: diethoxylation reaction, 200kg of water, 200kg of caustic soda, 110kg of catechol are added to the reaction kettle, and 385kg of diethyl sulfate is added dropwise; layer, separate the water layer, and the oil layer is the compound DEC;

[0037] The second step: nitration reaction, add 166kg compound DEC and 600kg glacial acetic acid into the reaction kettle, cool down to below 10 degrees, slowly add 110kg65% nitric acid dropwise, after the reaction is completed, the material is discharged and centrifuged to obtain compound NEC, and the mother liquor is distilled to recover ice acetic acid;

[0038] The third step: alkaline hydrolysis, put 86kg compound NEC, 350kg ethylene glycol monomethyl ether, 250kg water and 100kg potassium hydroxide into the reactor, heat and reflux for 30 hours, cool to 20 degrees, discharge and centrifuge to obtain compound red K, Mother liquor distillation reclaims the mixture of ethylene glycol monomethyl ether and water;

[0...

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Abstract

The invention discloses a preparing method of deccox, which uses cheap pyrocatechol as material to obtain deccox products with good quality and low cost by diethoxylation, nitration, alkali hydrolysis, decyloxylation, reduction, condensation, ring closing and hydrolyzation. Compared with the prior art, materials such as 3,4-dihydroxynitrobenzene or catechol ethylether, which are expensive and not easy to buy, are replaced by chemical materials, such as plate caustic soda, pyrocatechol, diethyl sulfate, glacial acetic-acid, nitric acid, glycol monoethyl ether, potassium hydroxide, bromodecane, phosphorus oxychloride, ethoxymethylene, sodium hydroxide, etc., which are cheap and easy to obtain, the reaction condition is gental, the integration cost is 50% lower than that of the prior art.

Description

Technical field: [0001] The invention relates to a preparation method of poultry medicine, in particular to a preparation method of dichnidine. Background technique: [0002] Antiballin, also known as decoquinate, can prevent and control E. tenella, E. maxima and E. acervulina , Poultry coccidiosis caused by poisonous Eimeria (E.necatrix), Eimeria brunetti (E.brunetti), variant Eimeria (E.mivati), etc. It works early in the coccidia life cycle and lasts the longest. It has a good effect on the six most harmful poultry coccidia. Play a role in the asexual reproduction stage of coccidia. After entering the sporozoite cell, it prevents its development by interfering with DNA synthesis. Dnifloxacin starts to play a role in the early life cycle of coccidia, so as to avoid damage to poultry intestines, and can more effectively help farmers obtain higher economic benefits. [0003] Product properties: [0004] Chinese name: enemy ball element, decoquinate; [0005] English n...

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Application Information

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IPC IPC(8): C07D215/56
Inventor 凌青云
Owner 凌青云
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