Adhesive skin patch

A patch and additive technology, applied in the direction of anti-inflammatory agents, non-central analgesics, skin care preparations, etc., can solve the problems of low melting point of gelatin, liquid dripping, and limited selection range of compounding substances, etc.

Active Publication Date: 2008-08-27
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gelatin-containing adhesive bases have a problem that the selection range of compounding substances is limited because gelatin has a pH range in which it exhibits shape retention and cohesion
In addition, the adhesive layer formed by the adhesive base containing gelatin has a problem of dripping when exposed to high temperature because of the low melting point of gelatin.

Method used

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  • Adhesive skin patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Add 0.5 parts by mass of "UP-37K" (trade name, manufactured by Ina Food Industry Co., Ltd.) as soluble agar to warm water at 70 to 80°C, gel strength: 700 g / cm 2 ), 0.5 parts by mass of synthetic aluminum silicate, 0.5 parts by mass of polyethylene glycol monostearate as a surfactant, and 3.0 parts by mass of polyvinyl alcohol were stirred at 70° C. to dissolve the raw materials. Then, move the total amount of this solution to a cooled stirrer, and then add 0.5 parts by mass of magnesium aluminosilicate metasilicate, 0.3 parts by mass of sodium edetate, and 1.0 parts by mass of L-mint A mixture of alcohol, 5.0 parts by mass of partially neutralized polyacrylic acid, and 30.0 parts by mass of glycerin, and further added purified water so that the total amount becomes 100 parts by mass. Cool the mixture at about 10°C and stir to prepare the adhesive base. When the solution of the soluble agar in the process of production was transferred to a cooled stirrer, the gelation ...

Embodiment 2-5

[0095] When preparing an adhesive base, except for the component composition shown in Table 1, it carried out similarly to Example 1, and prepared an adhesive base. When the solution of the soluble agar in the process of production was transferred to a cooled stirrer, the gelation state of the agar was observed, and it was considered that there was no gelation. Using the obtained adhesive base, it carried out similarly to Example 1, and obtained the patch. In addition, the same evaluation as Example 1 was performed about the obtained patch. The results are shown in Table 2.

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Abstract

Disclosed is an adhesive skin patch which has an adhesive layer comprising a readily-soluble agar and at least one additive selected from the group consisting of polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, sodium alginate, ammonium alginate, carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, gum arabic, tragacanth gum and xanthan gum.

Description

technical field [0001] The present invention relates to patches. Background technique [0002] In a patch having an adhesive layer containing a large amount of water, such as a paste or a sheet-like film, an adhesive base containing a water-soluble polymer such as gelatin, polyacrylic acid, or polyacrylate can be used to form the adhesive layer. In particular, an adhesive base containing gelatin is preferred because it has a high moisture content and excellent shape retention and cohesiveness. However, adhesive bases containing gelatin have a problem in that the selection range of compounding substances is limited because gelatin has a pH range in which shape retention and cohesion can be exhibited. In addition, an adhesive layer formed of an adhesive base containing gelatin has a problem of dripping when exposed to high temperature because gelatin has a low melting point. [0003] Here, an adhesive base containing agar in addition to gelatin has been proposed for the purp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/125A61K31/192A61K31/405A61K31/618A61K47/36A61K47/38A61P17/00A61P29/00
CPCA61K8/0208A61K8/73A61K8/8129A61K8/8147A61K9/7061A61K9/7069A61K31/125A61K31/192A61K31/405A61K31/618A61K2800/594A61Q19/00A61P17/00A61P29/00A61K9/70A61K47/36A61K47/38
Inventor 水流诚一郎日溪智行
Owner HISAMITSU PHARM CO INC
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