2results about How to "Reduce production process steps" patented technology

The invention relates to a furosemide tablet and a preparation method thereof.The furosemide tablet is prepared from, by weight, 25.00% of furosemide, 40%-45% of filler, 27%-33% of adhesive, 0.5%-1.5% of lubricant, 1.0%-2.0% of anti-sticking agent and 0.5%-1.5% of flow agent.The furosemide tablet is prepared by adopting the technology that purified water is directly added without preparing the adhesive; a wet granulation process is adopted, the controllability of process parameters in the production process is high, the human influence of operation of multiple process steps is reduced, the quality stability of the medicine is effectively improved, the quality of the medicine is equivalent to that of a commercially available reference preparation, and multiple dissolution curves are similar to that of the reference preparation; the in-vitro dissolution behavior similar to that of a reference preparation is shown, the quality is stable, and the dissolution behaviors among batches are consistent.

The application relates to the technical field of organic synthesis, and relates to a synthetic process of rifampicin by taking rifamycin O as a starting material, which comprises the following steps: after rifamycin O is hydrolyzed, a cyclization reaction is carried out on the hydrolyzed rifamycin O and dimethylol tertiary butylamine, and crystallization is carried out, so that rifamycin oxazine is obtained; a condensation reaction is carried out on the rifamycin oxazine and 1-methyl-4-aminopiperazine, and crystallization is carried out, so that rifampicin is obtained. Through the above technical scheme, the problems of low raw material output, insufficient purity and complex preparation in the production of rifampicin in the prior art are solved.