1results about How to "Reduce production process steps" patented technology

The application relates to the technical field of organic synthesis, and relates to a synthetic process of rifampicin by taking rifamycin O as a starting material, which comprises the following steps: after rifamycin O is hydrolyzed, a cyclization reaction is carried out on the hydrolyzed rifamycin O and dimethylol tertiary butylamine, and crystallization is carried out, so that rifamycin oxazine is obtained; a condensation reaction is carried out on the rifamycin oxazine and 1-methyl-4-aminopiperazine, and crystallization is carried out, so that rifampicin is obtained. Through the above technical scheme, the problems of low raw material output, insufficient purity and complex preparation in the production of rifampicin in the prior art are solved.