Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicament for preventing and treating prostate gland hyperplasia, abacterial prostatitis

A pharmaceutical preparation, a single technology, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2008-09-24
赵全成
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no relevant reports on the use of osthole monomer components in the prevention and treatment of diseases such as benign prostatic hyperplasia and non-bacterial prostatitis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicament for preventing and treating prostate gland hyperplasia, abacterial prostatitis
  • Medicament for preventing and treating prostate gland hyperplasia, abacterial prostatitis
  • Medicament for preventing and treating prostate gland hyperplasia, abacterial prostatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 osthole

[0027] Get Fructus Cnidii medical material 1kg, add calcium hydroxide (Ca(OH) 2 ) 10g, reflux extraction with 75% ethanol with 8 times the amount of medicinal materials, 3 times, 2 hours each time, filter, combine the filtrate, add 10g of activated carbon, fully stir, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water to the concentrate 1000ml, heated to 80°C, added sodium carbonate (NaCo 3 ) 15g, stirred for 15 minutes, then diluted to 1500ml with 80°C deionized water, stood at room temperature for 48 hours, filtered with suction, added 500ml of ethanol to the filter cake, heated to 80°C to dissolve, added 3g of activated carbon, stirred evenly, filtered, The ethanol was recovered from the filtrate to 100ml, placed, crystallized, the supernatant was filtered off, and the filter cake was dried to obtain 7.2g of light yellow osthole, with a content of 93.5% (as determined by HPLC).

Embodiment 2

[0028] The preparation of embodiment 2 osthole

[0029] Take 1kg of Cnidium chinensis medicinal material, add calcium oxide (CaO) 10g, reflux extract 3 times with 90% ethanol of 10 times the amount of medicinal material, each time for 2 hours, filter, combine filtrate, add activated carbon 10g, fully stir, filter, filtrate Recover ethanol until there is no alcohol smell, add water to the concentrated solution to adjust to 1000ml, heat to 80°C, add sodium carbonate (NaCo 3 ) 10g, stir for 15 minutes, then dilute to 1500ml with 80°C deionized water, let stand at room temperature for 48 hours, filter with suction, add 500ml of ethanol to the filter cake, heat to 80°C to dissolve, add 3g of activated carbon, fully stir, filter, The ethanol was recovered from the filtrate to 100ml, left to stand, crystallized, the supernatant was filtered off, and the filter cake was dried to obtain 8.1 g of light yellow osthole, with a content of 95.5% (as determined by HPLC).

Embodiment 3

[0030] Embodiment 3 (capsules)

[0031] 220g of osthole, 30g of medicinal starch, mix evenly, pass through a 16-mesh sieve to granulate, dry, granulate, pack into No. 1 capsules, and make 1000 capsules, to get final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a method used for extracting and purifying osthole from Chinese medicine of selinum by water-bearing ethanol, an appropriate amount of calcium hydroxide or calcium oxide, and other agents. The present invention also relates to oral taking preparations that are made of the osthole, and the application of preventing the proliferation of prostatic gland and non-bacterial prostatitis.

Description

technical field [0001] The invention relates to a medicine for preventing and treating prostate hyperplasia and nonbacterial prostatitis. Specifically, it relates to a preparation method of osthole and its new medical application, belonging to the field of traditional Chinese medicine. Background technique [0002] Cnidium monnieri (L.) cuss. is the dry and mature fruit of Cnidium monnieri (L.) cuss., which is a commonly used traditional Chinese medicine. It is used for the treatment of dampness arthralgia, lumbago, vulvar itching, leukorrhea, vaginal trichomoniasis, eczema, skin itching, impotence, and cervical infertility (New Chinese Medicine Journal, Vol. 2, p. 569). Cnidium contains coumarin compounds, the main component of which is osthole. Modern pharmacological studies have shown that osthole has anti-inflammatory, analgesic, anti-thrombotic, anti-arrhythmic, hypolipidemic, anti-tumor, prevention and treatment of osteoporosis and other effects (Chinese Journal of N...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D311/16A61K31/37A61K36/234A61P13/08
Inventor 赫玉芳初洪波赵全成南敏伦
Owner 赵全成
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com