Method for preparing miglitol midbody N-substituted-1-deoxidization nojirimycin derivative

A technology for miglitol and intermediates, which is applied in the field of preparation of N-substituted-1-deoxynojirimycin derivatives of miglitol intermediates, and can solve the problem of large differences between bacterial batches and high cost of biotransformation , unable to adapt to industrialized large-scale production and other problems, to achieve the effects of small bacterial loss, short processing time, and excellent slow-release performance
CN101270378BInactive Publication Date: 2013-05-01ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
Publication Date
2013-05-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of miglitol intermediate, in particular to a preparation method of a derivative of N-substitution-1-deoxynojirimycin which is the key intermediate of miglitol. Gluoconobacter oxydans or the Gluoconobacter oxydans treated by immobilized cell technology are used repeatedly for transforming the substrate to the derivative of N-substitution-1-deoxynojirimycin which is the miglitol intermediate, the transfer temperature is controlled at 5 to 25 DEG C, pH value is controlled at 4.0 to 6.5 and dissolved oxygen is controlled at 5 to 80 percent (in volume). Adopting the invention can decrease the biotransformation cost, reduce the inter-assay of cell, and be suitable for the large scale industrial production, increase the mechanical strength of the wall of the strain prepared, make the strain not to dissolve during the cultivation in long-term liquid environment, lengthen the service life and have outstanding slow release performance.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of Miglitol intermediate, especially, relate to the preparation method of N-substituted-1-deoxynojirimycin derivative of Miglitol key intermediate, specifically, adopt multiple mechanical oxidation A method for preparing miglitol intermediate 6-(2-hydroxyethyl)-amino-6-deoxy-α-L-sorbofuranose by gluconic acid bacteria or immobilized oxidative gluconic acid bacteria. Background technique

[0002] Miglitol, as a new type of α-glucosidase inhibitor, can effectively treat type II diabetes. Its main function is to reduce the postprandial blood sugar level of patients and reduce the occurrence of diabetic complications. It has quickly become the drug of choice.

[0003] The preparation method of the important intermediate N-substituted-1-deoxynojirimycin derivative as Miglitol synthesis mainly contains following several kinds at present: (1) Kinast etc. (KinastG, Schedel M.USP4 246 345.(1981 )) I...

Claims

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