Ginsenoside extract and its extraction method

A technology of ginsenosides and extraction methods, applied in the field of natural medicinal chemistry research, to achieve the effects of reducing production costs, obvious neurotrophic and nerve damage protection activities, and good market prospects

Inactive Publication Date: 2008-10-15
贵州三农楮桃产业开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the extraction of ginsenosides from the fruit of the fruit

Method used

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  • Ginsenoside extract and its extraction method
  • Ginsenoside extract and its extraction method
  • Ginsenoside extract and its extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Extract ginsenoside compounds from the fruit of the fruit of the fruit according to the following steps.

[0031] a, get dried mulberry fruit 100kg to grind and pulverize, the mulberry fruit after pulverizing is heated and refluxed extraction 4 times with 400l petroleum ether, each time 1.5 hours, filter, and the filter residue that obtains is A product;

[0032] b. Product A was decocted with 300l of water for 3 times, 2 hours each time, filtered, and the filtrate was combined. The filtrate was treated with D-101 macroporous adsorption resin, first eluted with distilled water, then eluted with 60% alcohol solution, and the alcohol was collected. Solution elution part, obtains B product;

[0033] c. Concentrate and dry product B to obtain ginsenoside extract.

[0034] The active ingredients of the ginsenoside extract contain one or more of Rg1, Rb1, Rb2, Rd, Rc, Re, Rf, Rg2 and Rh1.

Embodiment 2

[0035] Example 2: extract ginsenoside compounds from the fruit of the fruit of the fruit according to the following steps.

[0036] a, get dried 100kg of mulberry, grind and pulverize, extract 4 times with 300l of petroleum ether under reflux for the pulverized mulberry, filter for 1.5 hours each time, and the filter residue obtained is product A;

[0037] b. Product A was decocted with 200l of water for 3 times, 2 hours each time, filtered, and the filtrate was combined. The filtrate was treated with D-101 macroporous adsorption resin, first eluted with distilled water, then eluted with 70% alcohol solution, and the alcohol was collected. Solution elution part, obtains B product;

[0038] c. Concentrate and dry product B to obtain ginsenoside extract.

[0039] The active ingredients of the ginsenoside extract contain one or more of Rg1, Rb1, Rb2, Rd, Rc, Re, Rf, Rg2 and Rh1.

Embodiment 3

[0040] Example 3: Extract ginsenoside compounds from the fruit of the fruit of the fruit according to the following steps.

[0041] a, get dried mulberry fruit 100kg to grind and pulverize, the mulberry fruit after pulverizing is heated and refluxed extracted 4 times with 500l petroleum ether, each time 1.5 hours, filter, and the obtained filter residue is product A;

[0042] b. Product A was decocted 3 times with 300l of water, 2 hours each time, filtered, and the filtrate was combined. The filtrate was treated with D-101 macroporous adsorption resin, first eluted with distilled water, then eluted with 80% alcohol solution, and collected alcohol Solution elution part, obtains B product;

[0043] c. Concentrate and dry product B to obtain ginsenoside extract.

[0044] The active ingredients of the ginsenoside extract contain one or more of Rg1, Rb1, Rb2, Rd, Rc, Re, Rf, Rg2 and Rh1.

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Abstract

The invention discloses a ginsenoside extract and an extraction method thereof. The ginsenoside contains one or more effective ingredients selected from Rg1, Rb1, Rb2, Rd, Rc, Re, Rf, Rg2 and Rh1. The extraction method comprises the steps of: grinding dry Broussonetia papyrifera fruit, performing petroleum ether extraction or carbon dioxide supercritical extraction or water extraction under heating, and purifying with macroporous resin. The ginsenoside has remarkably nerve protecting, nerve nourishing, intelligence improving, and health promoting effects; has no toxicity to human body; and can be prepared into new drugs or natural health products for preventing or treating senile dementia.

Description

technical field [0001] The invention relates to a ginsenoside extract and an extraction method thereof, belonging to the field of natural medicine chemistry research. Background technique [0002] Ginsenoside is a general term for a class of saponins, which are mostly extracted from ginseng and Panax notoginseng, but its content is extremely low, and the price of raw materials is also high, which makes the extraction cost of ginsenosides very high. Ginsenosides have significant neuroprotective and neurotrophic activities, and have a good intellectual effect. They can be used for anti-aging, anti-fatigue, enhancing learning and memory, and treating dementia. They are also non-toxic to the human body and have considerable health effects. Therefore, It has become a new type of medicine and health food additive sought after by the world. [0003] Chushizi is the dry and mature fruit of Broussonetia papyrifera (L.) Vent., a moraceae tree. It is cheap and commonly used in traditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K131/00C07J9/00
CPCY02P20/54
Inventor 汪冶黄大健谢筠郁李海滨
Owner 贵州三农楮桃产业开发有限公司
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