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Fluorescence microscope

A fluorescence microscope, fluorescence technology, applied in the field of fluorescence microscope, can solve the problem of long measurement time

Active Publication Date: 2008-10-22
克勒克斯知识产权控股有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] A known disadvantage of fluorescence microscopy is that measurement times can become very long

Method used

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  • Fluorescence microscope

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Embodiment Construction

[0040] A fluorescence microscope is indicated generally at 1 and comprises a housing 10 with a camera 12 mounted thereon. Equipped in the housing 10 is an excitation light source 14 , as well as a first lens 16 , an excitation filter 18 and a dichroic mirror 20 .

[0041] exist figure 1 Equipped at the bottom of the housing 10 is an objective lens 22 through which a substrate 24 can be irradiated. A substrate 24 is accommodated in a substrate holder 26, while 28 designates an x-y-z substrate translation stage.

[0042] Reference numeral 30 designates a partial transmission mirror or beam splitter, 32 designates an emission filter, and 34 designates an imaging lens.

[0043] Indicated at the top of the housing 10 are a focusing light source 36 and a focusing lens 38 .

[0044] The housing 10 of the fluorescence microscope 1 according to the invention is a substantially light-tight housing. The housing 10 can in principle be made of any material such as metal and / or plastic....

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Abstract

The invention provides a fluorescence microscope and a method for using this to measure fluorescence. The microscope comprises a silicon wafer filter membrane which is highly- planar and does not fluoresce. Moreover, it has a very high perforation density, so that a small surface area is sufficient for effective measurement. Using a camera as the location-sensitive detector moreover makes it possible to take advantage of better optical resolution, which means that optics having a smaller numerical aperture and a smaller magnification factor can be employed, with a greater working distance. All these factors together provide a fluorescence microscope capable of much more rapid measurements than the existing fluorescence microscopes.

Description

technical field [0001] The present invention relates to fluorescence microscopy. [0002] Specifically, the present invention relates to a fluorescence microscope, which comprises: a housing with an excitation light source designed to emit excitation light; an optical filter that separates the excitation light from the fluorescence generated by the fluorescent substance; an objective lens; a substrate holder; a position sensitive photodetector; and an imaging lens for the position sensitive photodetector. Background technique [0003] This type of fluorescence microscope is widely used in the study of fluorescent samples or fluorescence studies of samples. Samples that do not inherently fluoresce can be provided with fluorescent substances if desired. If such a sample or sample is illuminated with appropriate light, usually but not exclusively visible or ultraviolet light, the fluorescent substances in the sample will be illuminated by fluorescent light having a wavelength...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/16
CPCY10T428/24802G02B21/16
Inventor F·H·A·G·费伊
Owner 克勒克斯知识产权控股有限公司