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Absorbent bone interface screw nail and preparation method thereof

An interface screw and surface modification technology, applied in medical science, surgery, etc., can solve the problems of insufficient degradation performance of composite materials and large particle size of calcium phosphate, and achieve increased strength, enhanced degradability, and large specific surface area. Effect

Inactive Publication Date: 2008-10-29
郑隆泗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle size of calcium phosphate in these composite materials is relatively large (about 1-100 μm), and the degradation performance of the composite materials is not good enough.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Dissolve 2.0 g of L-polylactic acid with an average molecular weight of 200,000 in 20 ml of dioxane at 50° C. to form a solution A with a concentration of 10% g / ml;

[0016] 2) Beta-tricalcium phosphate of 50 nanometers is joined in the 10 milliliters of stearic acid ethanol solution of 20% g / ml by 0.5g particle diameter, the concentration of nanometer beta-tricalcium phosphate in stearic acid ethanol solution 5% g / ml, treated at 50°C for 50 minutes, filtered out the powder, and dried to form surface-modified nano-beta-tricalcium phosphate;

[0017] 3) adding the surface-modified nano-beta-tricalcium phosphate into the solution A prepared in step 1), and forming a suspension B through stirring and ultrasonic dispersion;

[0018] 4) Prepare the suspension B in step 3) into thin slices with a thickness of 1mm by casting method, dry at 40°C, and then pulverize into granular materials, add them to an injection molding machine and inject them into a mold with the desired ...

Embodiment 2

[0020] 1) Dissolve 2.0 g of D-polylactic acid with an average molecular weight of 100,000 in 20 ml of dioxane at 60° C. to form a solution A with a concentration of 10% g / ml;

[0021] 2) 0.11g particle diameter is that 100 nanometers of beta-tricalcium phosphate is added to concentration in 10 milliliters of stearic acid ethanol solution of 10% g / ml, the concentration of nanometer beta-tricalcium phosphate in stearic acid ethanol solution 1.1% g / ml, treated at 75°C for 10 minutes, filtered out the powder, and dried to form surface-modified nano-beta-tricalcium phosphate;

[0022] 3) adding the surface-modified nano-beta-tricalcium phosphate into the solution A prepared in step 1), and forming a suspension B through stirring and ultrasonic dispersion;

[0023] 4) Prepare the suspension B in step 3) into thin slices with a thickness of 2mm by casting method, dry at 100°C, and then pulverize into granular materials, add them to an injection molding machine and inject them into a ...

Embodiment 3

[0025] 1) Dissolve 2.0 g of racemic polylactic acid with an average molecular weight of 1.2 million in 40 ml of dioxane at 20° C. to form a solution A with a concentration of 5% g / ml;

[0026] 2) 1.33g particle diameter is that the beta-tricalcium phosphate of 800 nanometers is joined in the 10 milliliters of stearic acid ethanol solution that concentration is 15% g / ml, the concentration of nanometer beta-tricalcium phosphate in stearic acid ethanol solution It is 13.3% g / ml, treated at 20°C for 600 minutes, filtered out the powder, and dried to form surface-modified nano-beta-tricalcium phosphate;

[0027] 3) adding the surface-modified nano-beta-tricalcium phosphate into the solution A prepared in step 1), and forming a suspension B through stirring and ultrasonic dispersion;

[0028] 4) Prepare the suspension B in step 3) into a thin sheet with a thickness of 5mm by casting method, dry at 130°C, and then crush it into granular material, add it to the injection molding machi...

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Abstract

The present invention discloses an absorbable bone interface screw and a preparation method thereof. The bone interface screw contains 5 to 40 percent of nanometer beta-tertiary calcium phosphate and 95 to 60 percent of polylactic acid by weight percentage. Nanometer beta-tertiary calcium phosphate powder is mixed with polylactic acid by solution; flow casting rapid drying method is adopted to evenly distribute the nanometer beta-tertiary calcium phosphate in the polymer matrix, thus molding in an injection machine. The bone interface screw provided by the present invention has the advantages of good biological activity and degradability, as well as very large specific surface area and high intensity.

Description

technical field [0001] The invention belongs to a composite material for bone and tendon repair and a preparation method thereof, in particular to an absorbable nano-beta-tricalcium phosphate reinforced bone interface screw and a preparation method thereof. Background technique [0002] Bone interface screws are used to attach the synapse to the bone. Traditionally made of metal materials. In recent years, the number of interface screws made of or degradable polymer materials has gradually increased. Its biggest feature is that it can degrade after being implanted in the human body. As the tissue heals, the implant slowly degrades. After the tissue heals, the implant is completely destroyed. Inhalation, so no secondary surgery. However, as the degradation time increases, the mechanical properties of this interface screw decrease too quickly; the acidic substances produced during the degradation process will cause aseptic inflammatory reactions in the tissue and affect tiss...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14
Inventor 郑隆泗翁文剑程逵
Owner 郑隆泗
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