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Microcurrent controlled chip device for fast detecting interface surface tension

A microfluidic chip and surface tension technology, applied in surface tension analysis and other directions, can solve the problems of large sample consumption, long measurement time, complex data processing process, etc. less effect

Active Publication Date: 2008-10-29
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods generally have the disadvantages of large sample consumption, long measurement time, and complicated data processing.

Method used

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  • Microcurrent controlled chip device for fast detecting interface surface tension
  • Microcurrent controlled chip device for fast detecting interface surface tension
  • Microcurrent controlled chip device for fast detecting interface surface tension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Use wet etching technology to process square grooves with widths of 50 microns and 210 microns on the glass substrate, and insert capillaries with an outer diameter of 45 microns, an inner diameter of 20 microns, and a capillary with an outer diameter of 200 microns and an inner diameter of 100 microns into the grooves. The coaxial sleeve structure is sealed and assembled into a chip using a glass slide as a cover plate. The chip device is used to measure the surface tension of aqueous solutions containing different concentrations of surfactant SDS, and the surface tension ranges from 33 to 72 mN / m. For different aqueous solution systems, the measured surface tension is compared with the literature value, and the deviation is within 2%. The sample consumption for each measurement is 10-30 μL.

Embodiment 2

[0043] Using mechanical micromachining technology, square grooves with widths of 105 microns and 360 microns are machined on the PMMA substrate, and capillaries with an outer diameter of 100 microns, an inner diameter of 50 microns, and a capillary with an outer diameter of 350 microns and an inner diameter of 250 microns are embedded in the grooves. The coaxial sleeve structure uses a plexiglass sheet with a thickness of 1mm as a cover plate to seal and assemble the chip. The chip device is used to measure the interfacial tension of n-butanol-water, n-octanol-water, benzene-water, toluene-water and other liquid-liquid systems, and the interfacial tension ranges between 1.7 and 40 mN / m. For different liquid-liquid systems, the measured interfacial tension is compared with the literature value, and the deviation is within 3%. The sample consumption for each measurement is 60-150 μL.

Embodiment 3

[0045] Using mechanical micromachining technology, square grooves with widths of 310 microns and 710 microns were machined on the PMMA substrate, and capillaries with an outer diameter of 300 microns, an inner diameter of 150 microns and a capillary with an outer diameter of 700 microns and an inner diameter of 500 microns were embedded in the grooves. The coaxial sleeve structure uses a plexiglass sheet with a thickness of 1mm as a cover plate to seal and assemble the chip. The chip device is used to measure the interfacial tension of a liquid-liquid system in which the water phase is an aqueous solution containing different concentrations of surfactant Tween 20 and the oil phase is n-hexane. The interfacial tension ranges from 4.6 to 51 mN / m. For different liquid-liquid systems, the measured interfacial tension is compared with the literature value, and the deviation is within 2%. The sample consumption for each measurement is 200-300 μL.

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Abstract

The invention discloses a microfluidic chip device for quickly measuring interfacial or surface tension, and belongs to the microfluidic chip field. The composition of the device comprises a substrate and a cover plate. A cross-form groove is disposed on the base material of the substrate; a disperse phase fluid inlet pipe and a fluid outlet pipe are respectively inlaid in the groove to form a coaxial sleeve structure; a continuous phase fluid inlet pipe is embedded in a groove on the two sides and connected with the coaxial sleeve; and the cover plate is hermitically attached to the upper surface of the substrate and seals the groove. The microfluidic chip device has the advantages of simple structure, convenient processing, easy batch production, quick and high-efficient measurement, small usage of samples, accuracy and reliability. Furthermore, the device is applicable to measuring the interfacial or the surface tension with high volatility, highly toxicity or surface active agent system, and has wide application prospect in basic research and industrial production.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chips, and in particular relates to a microfluidic chip device for rapidly measuring interfacial surface tension. Background technique [0002] In the early 1990s, analytical chemists proposed the idea of ​​Micro Total Analysis System (μTAS). The micro-analysis system integrates the common functions of the entire analytical chemistry laboratory into a centimeter or even millimeter-scale platform, making it miniaturized, automated, highly integrated and portable. At present, the micro-total analysis system has had a great influence in the field of analytical instruments and analytical science, and has become a current research hotspot, and guides the development of analytical chemistry and biochemical technology towards the trend of miniaturization, integration and portability. In the micro total analysis system, the microfluidic chip is the main research direction. Using micromachining tech...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N13/02
Inventor 徐建鸿骆广生李少伟兰文杰谭璟
Owner TSINGHUA UNIV