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Active extract containing phlorizin and uses thereof

A technology of extract and phlorizin, applied in the field of active extract containing phlorizin and its application, can solve the problems of simplicity and no process

Active Publication Date: 2008-11-05
CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But so far, there is still no extraction method with simple process, low cost and suitable for large-scale production to prepare high-content phlorizin, and there is no active extraction method suitable for preparing pharmaceutical compositions with high phloridin content. thing

Method used

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  • Active extract containing phlorizin and uses thereof
  • Active extract containing phlorizin and uses thereof
  • Active extract containing phlorizin and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Add 8 times the amount of apple juice waste into 70% ethanol aqueous solution, soak for 2 hours, heat to reflux state, and reflux for 1 hour, filter; add 6 times the amount of 70% ethanol aqueous solution to the filter residue, heat to reflux state and Reflux for 1 hour, filter; repeat this process 1 time. Combine the filtrates, concentrate under reduced pressure to recover ethanol, and obtain phlorizin extract.

[0059] Put 30g of phloridzin dry extract in 100ml of distilled water, heat to 80°C and keep stirring to dissolve the phloridin completely, and filter while hot to obtain a brownish-brown clear solution, let it stand and cool to 20-40°C, and the solution Add to the head end of 100-200 mesh polyamide, elute with distilled water to remove part of the water-soluble impurities and pigments, then elute with 10%-40% ethanol aqueous solution, TLC detection, collect the end eluate, concentrate and filter, The filtrate was allowed to stand for crystallization, and the ...

Embodiment 2

[0067] Cut the tender branches and leaves of apples into small sections of 1 to 3 cm, add 10 times the amount of 50% ethanol aqueous solution, soak for 30 minutes, heat to reflux state, and reflux for 1 hour, filter; add 5 times the amount of 50% ethanol to the filter residue The aqueous ethanol solution was heated to reflux and refluxed for 1 hour, then filtered; this process was repeated once. Combine the filtrates, recover ethanol under normal pressure, and concentrate to obtain phlorizin extract.

[0068]Put 30g of phloridzin dry extract in 100ml of distilled water, heat to 80°C and keep stirring to dissolve the phloridin completely, and filter while hot to obtain a brownish-brown clear solution, let it stand and cool to 20-40°C, and the solution Added to the head of polyamide, eluted with distilled water to remove some water-soluble impurities and pigments, then eluted with 30%-40% ethanol aqueous solution, TLC detection, collected the eluate at the end, concentrated and ...

Embodiment 3

[0070] Make tablet of the present invention by following formula: (all content used is weight percent composition)

[0071] Active extract with phlorizin 70% 54.5%

[0072] Microcrystalline Cellulose 42.0%

[0073] PVP-k30 1.0%

[0074] Magnesium Stearate 0.5%

[0075] Sodium Carboxymethyl Starch 2.0%

[0076] Mix phlorizin extract, microcrystalline cellulose, and part of carboxymethyl starch sodium, add PVP-k30 ethanol solution to make soft material, granulate through a 20-mesh sieve, granulate after air-drying at 60°C, add carboxymethyl starch Sodium methyl starch and magnesium stearate are mixed evenly and pressed into tablets.

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Abstract

The invention discloses an active extract, the active extract is obtained by using ethanol water solution with 5 to 95 percent as a solvent to carry out the extraction from rosaceae and fagaceae plants, the content of phlorizin in the active extract is 30 to 99.5 percent; the invention further discloses a preparation method of the active extract and a usage thereof in the preparation of drugs for treatment for diabetic nephropathy and hepatic edema.

Description

technical field [0001] The invention relates to an active extract mainly containing phlorizin extracted from Rosaceae and Fagaceae plants, and the active extract is used for preparing a pharmaceutical composition for treating diabetic nephropathy and liver edema. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN), diabetic glomerulosclerosis, is a common and refractory microvascular complication of diabetes, and is the main cause of death in diabetes. [0003] The evolution of renal function and structural lesions in diabetic patients can be divided into the following five stages: Stage I: characterized by high glomerular filtration rate (GFR offside 150ml / min) and renal enlargement. Stage II: Asymptomatic renal damage stage, but with structural damage of glomerular matrix membrane thickening. A reversible increase in urinary albumin excretion (UAE) can occur after exercise. Stage III: High-risk period of diabetic nephropathy, UAE continues to ri...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/00A61P1/16A61P3/10A61P13/12A61K125/00A61K127/00A61K129/00A61K131/00A61K135/00
Inventor (请求不公开姓名)
Owner CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
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