Surgery biological sticking patch and preparation method thereof

Abstract

The invention belongs to the biomedical engineering field, in particular relating to a surgical biological patch and a preparation method thereof. The surgical biological patch takes a decellation technology as the basis and a biological source epithelial tissue material as a raw material, is mainly applicable to the stanching and the air leakage prevention of a lung wound surface after a thoracic surgery operation, and can be used for the stanching of wound surfaces of various parenchymal viscera (such as livers, spleens and so on).

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a surgical biological patch and a preparation method thereof. Background technique [0002] Hemorrhage and air leakage from wounds of various solid organs are common complications during surgery. Taking thoracic surgery as an example, after various types of lung surgery, the bleeding and air leakage of the wound surface of the lung tissue prolong the operation time and increase the mortality rate of the operation. Small amounts of bleeding and air leaks from stitch holes can heal on their own. Severe postoperative bleeding, exceeding 200ml per hour, requires emergency thoracotomy to stop bleeding. Severe postoperative air leaks (greater than 7 days, approximately 15% of all patients) suggest bronchopleural leaks, often leading to empyema, requiring prolonged or replaced chest tubes, intrapleural chemical injections causing pleural adhesions, and even re-opening...

AI Technical Summary

Problems solved by technology

Suture reinforcement seems to be the most economical and convenient option, but this method increases the operation time and is not suitable for the treatment of large lung wounds

Because the suturing will lead to normal lung tissue atelectasis, and the suture surface is highly tense, there are often negative reports of air leakage at the needle hole during the lung filling period, and often tearing of the anastomotic port, resulting in re-bleeding and air leakage.

At present, all clinical and animal experimental research results on bioglue have failed to provide convincing evidence to prove that it has the effect of strengthening the sutured tissue strength and reducing the incidence of bleeding and air leakage

Moreover, the bioglue tends to dissolve too fast, has weak strength, has poor adhesion to lung tissue after coagulation, is easy to fall off, and is expensive and cumbersome to use.