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Biodegradable temperature/pH dual responsiveness aquagel

A temperature-responsive and responsive technology, used in the field of biomedical polymer materials to achieve excellent water absorption

Inactive Publication Date: 2010-06-09
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] As far as our research is concerned, there have been no literature or patent reports on hydrogels based on biodegradable polyphosphates with dual temperature / pH responsive properties.

Method used

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  • Biodegradable temperature/pH dual responsiveness aquagel
  • Biodegradable temperature/pH dual responsiveness aquagel
  • Biodegradable temperature/pH dual responsiveness aquagel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 4

[0052] One, the synthesis of embodiment 1 to 4 cross-linking agent polyphosphate macromonomer:

Embodiment 1

[0053] Example 1: HEMA-PEOP-Ac (EOP: HEMA: Sn(Oct) 2 =150:5:3) synthetic method

[0054] Dry the reaction bottle and stirrer in an oven at 120°C for at least 6 hours in advance. After taking it out, plug it tightly with a reversible rubber stopper, and then use a vacuum oil pump to vacuumize while filling it with high-purity argon, repeating several times until the reaction bottle cools down.

[0055] Inject 6.8860g monomer EOP (45.3mmol), 0.1965g initiator HEMA (1.51mmol) and 0.3670g catalyst Sn(Oct) into the bottle sequentially with a dry syringe 2 (0.91mmol), and then evacuated and filled with high-purity argon three times. Finally, the reaction bottle was placed in an oil bath with a preset temperature of 45° C., and after 3 hours of reaction, the stopper was opened to stop the reaction.

[0056] The crude reaction product was precipitated three times in a large amount of ice anhydrous ether, and then dried in a vacuum oven at 30°C for 24 hours to obtain 6.0810 g of a c...

Embodiment 2

[0058] Example 2: HEMA-PEOP-Ac (EOP: HEMA: Sn(Oct) 2 =50:5:3) synthetic method

[0059] Put the reaction bottle and stirring bar in an oven at 120°C to dry for at least 6 hours in advance. After taking it out, plug it tightly with a rubber stopper, and then use a vacuum oil pump to vacuum while filling it with high-purity argon. Repeat several times until the reaction bottle cools down.

[0060] Inject 1.2170g monomer EOP (8mmol), 0.1042g initiator HEMA (0.8mmol), and 0.1944g catalyst Sn (Oct) into the bottle successively with a dry syringe 2 (0.48mmol), and then evacuated and filled with high-purity argon three times; finally, the reaction bottle was placed in a 45°C oil bath with a preset temperature, and after 3 hours of reaction, the stopper was opened to stop the reaction.

[0061] The reaction crude product was precipitated three times in a large amount of ice anhydrous ether, and then dried in a vacuum oven at 30°C for 24 hours to obtain 1.0760 g of a colorless, transp...

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Abstract

The invention discloses biodegradable temperature / pH dual response hydrogel and a preparation method thereof. The method comprises the following steps that: a temperature response polyphosphate estermacromonomer is taken as a crosslinking agent, and reacts with a pH sensitive monomer for radical polymerization for 12 to 24 hours at a temperature of between 30 and 50 DEG C, and then the hydrogel is prepared. The hydrogel provided by the invention utilizes temperature sensitive polyphosphate ester to replace the prior temperature sensitive acrylamide polymer, and overcomes the defect that the prior temperature sensitive hydrogel is mostly formed by polymers with poor degradability. The hydrogel provided by the invention has superior water absorption, permeability, biocompatibility, degradability and temperature / pH sensitivity, is a novel artificially synthesized macromolecular hydrogel material, and is widely used in biomedicine and other prospects, for example, the hydrogel can be taken as a biomedical material such as a medicine slow release carrier or a tissue engineering cell culture support and so on.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a biodegradable temperature / pH double responsive hydrogel and a preparation method thereof. Background technique [0002] Smart hydrogels, also known as sensitive hydrogels, refer to those that can sense small changes or stimuli in the external environment (such as temperature, pH value, light and biomolecules, etc.), and can produce corresponding changes in physical structure and chemical properties. A class of polymer hydrogels. Due to the intelligence of sensitive hydrogels, it is possible to be applied in many fields, especially in the sustained release of drugs, the separation and purification of proteins, the embedding of active enzymes, and artificial muscles. Therefore, its research has been widely concerned by scholars at home and abroad. [0003] Among the numerous sensitive hydrogels, temperature or pH sensitive hydrogels have become ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F290/06C08G79/04
Inventor 倪沛红何金林王赛张明祖
Owner SUZHOU UNIV