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Compound thrombolytic and pericardium clearing complex capsule and preparation method thereof

A technology of Tongxinluo and capsules, which is applied in the field of improved drugs for the treatment of cardiovascular and cerebrovascular diseases, can solve the problems of unsatisfactory treatment of cardiovascular and cerebrovascular diseases, difficulty in controlling the dosage ratio and course of treatment, and achieve the effect of inhibiting aggregation

Inactive Publication Date: 2009-01-07
马继龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned single Chinese medicine leech and western medicine aspirin each have their own specialties, but the suddenness of the disease often does not appear in a single form of symptoms. The ratio and course of treatment are difficult to control, and the treatment of cardiovascular and cerebrovascular diseases is unsatisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The whole leech of Fufang Rongshuan Tongxinluo Capsules is the whole Japanese leech specially raised in the artificial pool, which is oblate and long cylindrical, composed of many links, 2-5cm long, 0.2-0.3cm wide, and the back is dark green or black. Brown, with 5 yellow-brown lines, wash with clean water and mix with plant ash, then wash with clean water, absorb water and dry in the air. The whole leech is crushed and developed into powder, screened through 120-150 mesh, and then sterilized with ultraviolet light for 5-20 minutes; weigh out 360 grams of leech medicine powder for use; then weigh out 20 grams of powdered aspirin, and fully Mix and stir evenly; then put 475 mg of the two synergistic combination drugs in capsules, so that each capsule contains 450 mg of leeches and 25 mg of aspirin, thus completing the synergistic combination of Chinese and Western medicines, and then quantifying the capsules according to the course of treatment. Comes in a sealed box or ...

Embodiment 2

[0012] The whole leech of Fufang Rongshuan Tongxinluo Capsules adopts the whole wide-body golden leech, which is flat and spindle-shaped, composed of many links, 4-10cm long, 0.2-0.5cm wide, and the back is dark brown or dark brown. Slightly raised, with black spots arranged in 5 vertical lines, washed with clean water, mixed with plant ash, then washed with clean water, and then dried after absorbing water. The whole leech is crushed and developed into powder, then screened with 120-150 mesh, and then sterilized with ultraviolet light for 5-20 minutes, and 450 mg of powdered aspirin is weighed out for later use; 25 mg of powdered aspirin is weighed out, and the two kinds of powders are mixed to make Stir well and evenly, and then put the powder into capsules according to a certain weight, so that each capsule contains 450mg of leeches and 25mg of aspirin, thus completing the application of two synergistic combinations of Chinese and Western medicines, and then sealing the caps...

example 1

[0014] Prevention and treatment of more than 4,000 patients with cardiovascular and cerebrovascular diseases caused by high blood viscosity. The prevention method is to take capsules orally, 3 times a day, 2 capsules each time, after 1 course of treatment (60-90 days).

[0015] Clinical case 2

[0016] The method of treatment is oral capsule, 2 times on the 1st, each 3 capsules, through 2 courses of treatment (90~180 days), make the patient reach relief, or return to normal basically.

[0017] Clinical case 3

[0018] For patients with obvious abnormal blood rheology, there is a comparison table with the treatment of Naoxintong for those with symptoms of insufficient blood supply of cardiovascular and cerebrovascular vessels.

[0019] Table 1 Based on symptom improvement and hemorheological changes

[0020] group

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Abstract

The invention provides a compound capsule with thrombolytic and heart meridians dredging effects and a preparation method thereof. The compound capsule is prepared from hirudo and aspirin. The hirudo is Hirudo nipponia artificially fed in a special pond, which has a flat and long cylindrical shape, is composed of multiple segments, has five yellow-brown colored lines, and has a dark green-colored or black-brown colored back; or Whitmania pigra which has a flat spindle shaped and is composed of multiple segments. The preparation method comprises the steps of: collecting hirudo, suffocating, washing with clear water, air-drying or oven-drying, crushing, sieving to obtain powder, and sterilizing; and collecting aspirin which is odorless pure white crystalline powder with sourish taste, mixing the hirudo powder and aspirin at a weight ratio of 18:1, mixing, stirring, encapsulating with a specification of 475 mg, and packaging. The inventive compound capsule can be used for preventing cerebrovascular sclerosis, cardiovascular sclerosis, increase of blood viscosity, cerebral thrombosis, severe breast pain caused by angina pectoris and myocardial infarction, etc.

Description

technical field [0001] The invention relates to an improved drug for treating cardiovascular and cerebrovascular diseases, in particular to a compound lysing thrombosis Tongxinluo capsule and a preparation method thereof. Background technique [0002] At present, there are many kinds of medicines prepared by using leeches, and leeches have antithrombotic and anticoagulant effects, as well as thrombolytic and blood fat-lowering effects. A kind published on the Chinese patent: "Compound Miqitong for the treatment of cardiovascular diseases and its preparation method" (CN 94115820) is prepared by using 35-70% leeches and 30-65% soil worms to treat coronary heart disease and myocardial infarction , cerebral infarction, sequelae of cerebral hemorrhage, angina pectoris, etc., without toxic and side effects. There is another "medicine for treating retinal vein embolism and its preparation process" (CN96118718), which is obtained from the extract of a single Chinese medicine leech,...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K9/48A61P9/10A61P7/02A61K31/616
Inventor 马继龙
Owner 马继龙
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