Unlock instant, AI-driven research and patent intelligence for your innovation.

Synthesis of substituted pachyman

A technology of polysaccharides and synthesis methods of Poria cocos, applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of difficulty in suction filtration or centrifugal separation, large consumption of organic solvents, low yield, etc., and achieve easy operation and processing , Accelerate the reaction speed and increase the degree of substitution of the product

Inactive Publication Date: 2012-03-21
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former has low yield, large consumption of organic solvents, and high cost; the latter is leached with alkaline solution, neutralized with acid to precipitate the polysaccharides, and the polysaccharides are viscous peptone-like in acidic medium, which is difficult to filter or centrifuge separate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis of substituted pachyman
  • Synthesis of substituted pachyman
  • Synthesis of substituted pachyman

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 in NaOH aqueous ethanol solution, the synthesis of carboxymethylpachyran

[0029] Add solid NaOH (3.0g, 75mmol) and 85% ethanol (20mL) to a 50mL single-necked round-bottom flask successively to dissolve NaOH, then add 1.0g of Poria cocos powder, alkalinize for 0.5h under the action of ultrasonic waves, and then add chloroacetic acid (1.17 g, 12.4mmol), under the continuous action of ultrasound, react at 50°C for 50 minutes, separate layers, pour off the supernatant, dissolve the paste in the lower layer in a small amount of alkali, neutralize with glacial acetic acid, precipitate with alcohol, filter with suction, wash, Freeze-dried to obtain a white powder with a measured degree of substitution of 0.68.

Embodiment 2

[0030] Embodiment 2 in NaOH urea aqueous solution, the synthesis of methylpachyran

[0031] Add 1.5M NaOH / 0.5M urea aqueous solution (18.5mL) into a 50mL single-necked round-bottom flask, then add 1.0g of poria cocos powder, alkalinize for 1.0h under the action of ultrasonic waves, then add dimethyl sulfate (1.75g, 13.9mmol), and ultrasonically Continue to react at 60°C for 60 minutes, neutralize with glacial acetic acid, filter with suction, wash, and freeze-dry to obtain a white powder with a measured substitution degree of 0.51.

Embodiment 3

[0032] Embodiment 3 in NaOH urea aqueous solution, the synthesis of hydroxyethylpachyran

[0033] Add 1.5M NaOH / 0.5M urea aqueous solution (25mL) into a 50mL single-necked round-bottom flask, then add 1.0g of Poria cocos powder, alkalinize for 1.0h under the action of ultrasonic waves, then slowly drop 2-chloroethanol (1.0g, 12.4mmol) into In the reaction system, it was reacted at 60° C. for 90 minutes under the action of ultrasound, neutralized with glacial acetic acid, filtered with suction, washed, and freeze-dried to obtain a white powder with a measured substitution degree of 0.42.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of substitutionaaaaaaaaaa
degree of substitutionaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of polysaccharide, which aims at providing a synthetic method replacing pachymaran. In order to realize the purpose, the preparation method adopts the detailed technical steps: firstly, the ethanol aqueous solution of NaOH or NaOH / urea aqueous solution is added in poria powder and is alkalified under the effect of ultrasonic wave for 30 minutes to 90minutes; secondly, the reaction reagent is added in a reaction system to react for 50 minutes to 90 minuets under the effect of ultrasonic wave and the temperature of 50 DEG C to 70 DEG C, the mol ratio of the NaOH and the reaction reagent is 2 to 6 : 1, and the use amount of the ethanol aqueous solution or the urea aqueous solution is 20 mL / 1g to 30 mL / 1g of poria powder; and thirdly, the targetproduct is obtained through leaching and acid washing the mixture obtained after reaction to neutrality and edulcoration. The preparation method has the advantages that the preparation method can perform one-step synthesis replacing pachymaran, the operation is convenient and time saving, and the cost is reduced; the ultrasonic wave is used to assist, the reaction speed is accelerated, and the substitution degree of the product is enhanced; the solution is secure, nontoxic and tractable.

Description

technical field [0001] The invention relates to a preparation method of polysaccharide, in particular to a method for synthesizing substituted polysaccharides. Background technique [0002] Poria cocos (Schw.) Wolf is a traditional Chinese medicinal material that is used for both medicine and food. Poria cocos polysaccharide is the main functional component of Poria cocos, which contains about 93% in the medicinal part of Poria cocos sclerotia. Poria cocos polysaccharides can be divided into water-soluble polysaccharides and alkali-soluble polysaccharides, most of which are alkali-soluble polysaccharides, and their monosaccharide components are mainly glucose. Alkali-soluble pachyranan has low activity and almost no anti-tumor activity (0-3%), while the water-soluble polysaccharide substituted by chemical modification of alkali-soluble pachyan has higher anti-tumor activity. In the tumor test, the inhibition rate can reach more than 90%, so it has good development value an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P35/00
Inventor 王永江吴学谦毛建卫
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY